Tamlosin 0.4 mg (Tablet)

Unit Price: ৳ 10.07 (2 x 20: ৳ 402.80)
Strip Price: ৳ 201.40

Medicine Details

Category Details
Generic Tamsulosin hydrochloride
Company Orion pharma ltd

Indications

  • Treatment of functional symptoms of Benign Prostatic Hyperplasia (BPH)

Pharmacology

  • Selective alpha1 adrenoceptor blocking agent
  • Relaxes smooth muscle in bladder neck and prostate
  • Improves urine flow rate
  • Reduces symptoms of BPH
  • Complete absorption (90%) following oral administration under fasting conditions
  • Highly bound to human plasma protein (94% to 99%)
  • Extensively metabolized by liver enzymes
  • Elimination half-life ranges from five to seven hours
  • Absorption rate controlled pharmacokinetics
  • Apparent half-life approximately 9 to 15 hours

Dosage & Administration

  • 0.4 mg (one capsule) daily, to be taken after meal at night
  • Dose may be increased to 0.8 mg (two capsules) once daily after 2 to 4 weeks
  • Capsule should be swallowed whole with a glass of water
  • Should not be crunched or chewed

Interaction

  • Concurrent administration of other alfa1-adrenoceptor antagonists could lead to hypotensive effects
  • No interactions seen with atenolol, enalapril, or nifedipine
  • Cimetidine raises and frusemide lowers plasma levels of Tamlosin
  • No interactions at the level of hepatic metabolism with certain drugs
  • Diclofenac and warfarin may increase the elimination rate of Tamlosin

Contraindications

  • Hypersensitivity to Tamsulosin hydrochloride
  • History of orthostatic hypotension
  • Severe hepatic insufficiency
  • Possible reduction in blood pressure
  • Caution advised to avoid activities where injury could result
  • Examination and testing recommended before therapy is initiated

Side Effects

  • Dizziness
  • Abnormal ejaculation
  • Headache
  • Asthenia
  • Postural hypotension
  • Palpitations

Pregnancy & Lactation

  • Not recommended for use in pregnancy and lactation

Precautions & Warnings

  • Rare transient postural symptoms observed
  • Use not advised in patients with micturition syncope
  • Dizziness may occur
  • Effects on ability to drive and use machines uncertain

Overdose Effects

  • Acute hypotension likely after overdosage
  • Cardiovascular support recommended
  • Renal function monitoring and general supportive measures
  • Dialysis unlikely to be helpful
  • Measures such as emesis and gastric lavage may be taken to impede absorption

Therapeutic Class

  • BPH/Urinary retention/Urinary incontinence

Storage Conditions

  • Store in a cool and dry place, below 30°C, protected from light

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