Uroflo 0.4 mg (Capsule (Modified Release))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Tamsulosin hydrochloride
Company Beximco pharmaceuticals ltd

Indications

  • Treatment of functional symptoms of Benign Prostatic Hyperplasia (BPH)

Pharmacology

  • Selective alpha1 adrenoceptor blocking agent
  • Relaxes smooth muscle in bladder neck and prostate
  • Improves urine flow rate
  • Reduces symptoms of BPH
  • Absorption of Tamsulosin hydrochloride capsule 0.4mg is essentially complete (90%)
  • Time to maximum concentration (Tmax) is reached by four to five hours under fasting conditions
  • Extensively metabolized by cytochrome P 450 enzymes in the liver
  • Elimination half-life of Tamsulosin hydrochloride in plasma ranges from five to seven hours

Dosage & Administration

  • Tamsulosin Hydrochloride 0.4 mg (one capsule) daily, to be taken after meal at night
  • Dosage may be increased after 2 to 4 weeks, if necessary
  • Capsule should be swallowed whole with a glass of water (about 150 ml) in the standing or sitting position

Interaction

  • Concurrent administration of other alfa1-adrenoceptor antagonists could lead to hypotensive effects
  • No interactions seen when given concomitantly with atenolol, enalapril, or nifedipine
  • Concomitant cimetidine brings about a rise and frusemide a fall in plasma levels of Uroflo
  • Diclofenac and warfarin may increase the elimination rate of Uroflo

Contraindications

  • Hypersensitivity to Tamsulosin hydrochloride
  • History of orthostatic hypotension
  • Severe hepatic insufficiency

Side Effects

  • Dizziness
  • Abnormal ejaculation
  • Headache
  • Asthenia
  • Postural hypotension
  • Palpitations

Pregnancy & Lactation

  • Not recommended for use

Precautions & Warnings

  • Transient postural symptoms have occurred during orthostatic provocation testing after the first dose
  • Use in patients with micturition syncope is not advised
  • Effects on ability to drive and use machines

Overdose Effects

  • Acute hypotension likely to occur after overdosage
  • Cardiovascular support should be given
  • Renal function should be monitored
  • General supportive measures should be applied
  • Dialysis is unlikely to be of help

Therapeutic Class

  • BPH/ Urinary retention/ Urinary incontinence

Storage Conditions

  • Store in a cool and dry place, below 30°C, protected from light

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