Urolosin 0.4 mg (Tablet)

Unit Price: ৳ 10.07 (2 x 14: ৳ 282.00)
Strip Price: ৳ 141.00

Medicine Details

Category Details
Generic Tamsulosin hydrochloride
Company General pharmaceuticals ltd

Indications

  • Treatment of functional symptoms of Benign Prostatic Hyperplasia (BPH)

Pharmacology

  • Selective alpha1 adrenoceptor blocking agent
  • Relaxes smooth muscles in bladder neck and prostate
  • Improvement in urine flow rate
  • Reduction in symptoms of BPH
  • Complete absorption (90%) under fasting conditions
  • Time to maximum concentration reached by four to five hours under fasting conditions
  • Extensively metabolized by cytochrome P 450 enzymes in the liver
  • Elimination half-life ranges from five to seven hours

Dosage & Administration

  • Tamsulosin Hydrochloride 0.4 mg (one capsule) daily
  • To be taken after meal at night
  • Dose may be increased to 0.8 mg (two capsules) once daily if necessary
  • Swallowed whole with a glass of water in standing or sitting position
  • Not to be crunched or chewed

Interaction

  • Concurrent administration with other alfa1-adrenoceptor antagonists could lead to hypotensive effects
  • No interactions seen with atenolol, enalapril, or nifedipine
  • Cimetidine brings about a rise, frusemide brings about a fall in plasma levels of Urolosin
  • No interactions at the level of hepatic metabolism seen during in vitro studies with liver microsomal fractions
  • Diclofenac and warfarin may increase the elimination rate of Urolosin

Contraindications

  • Hypersensitivity to Tamsulosin hydrochloride
  • History of orthostatic hypotension
  • Severe hepatic insufficiency
  • Reduction in blood pressure can occur in individual cases
  • Avoid situations where injury could result
  • Patient should be examined to exclude other conditions which can cause the same symptoms as Benign Prostatic hyperplasia
  • Digital rectal examination and determination of Prostate Specific Antigen (PSA) should be performed before treatment and at regular intervals afterwards

Side Effects

  • Dizziness
  • Abnormal ejaculation
  • Headache
  • Asthenia
  • Postural hypotension
  • Palpitations

Pregnancy & Lactation

  • Not recommended for use during pregnancy and lactation

Precautions & Warnings

  • Transient postural symptoms have occurred during orthostatic provocation testing after the first dose
  • Use in patients with micturition syncope is not advised
  • No data available on whether Urolosin adversely affects the ability to drive or operate machines
  • Patients should be aware of the possibility of dizziness

Overdose Effects

  • Acute hypotension likely to occur
  • Cardiovascular support should be given
  • Blood pressure can be restored and heart rate brought back to normal by lying the patient down
  • Volume expanders and vasopressors could be employed if necessary
  • Renal function should be monitored
  • General supportive measures should be applied
  • Dialysis unlikely to be of help as Urolosin is very highly bound to plasma proteins
  • Measures such as emesis, gastric lavage, activated charcoal, and osmotic laxative can be taken to impede absorption

Therapeutic Class

  • BPH/ Urinary retention/ Urinary incontinence

Storage Conditions

  • Store in a cool and dry place below 30°C
  • Protected from light

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