Tamcontin 0.4 mg (Tablet)

Unit Price: ৳ 11.00 (3 x 10: ৳ 330.00)
Strip Price: ৳ 110.00

Medicine Details

Category Details
Generic Tamsulosin hydrochloride
Company Mundipharma bd pvt ltd

Therapeutic Class

  • BPH
  • Urinary retention
  • Urinary incontinence

Indications

  • Treatment of functional symptoms of Benign Prostatic Hyperplasia (BPH)

Pharmacology

  • Selective alpha1 adrenoceptor blocking agent
  • Relaxation of smooth muscles in the bladder neck and prostate
  • Improvement in urine flow rate
  • Reduction in symptoms of BPH
  • High absorption rate (90%) under fasting conditions
  • Time to maximum concentration (Tmax) reached by 4-7 hours
  • Extensive metabolism by cytochrome P450 enzymes in the liver
  • Plasma protein binding rate of 94% to 99%
  • Elimination half-life of 5 to 7 hours
  • Apparent half-life of 9 to 15 hours

Dosage & Administration

  • Initial dose of Tamsulosin Hydrochloride 0.4 mg (one capsule) daily
  • Increased dose of Tamsulosin Hydrochloride to 0.8 mg (two capsules) once daily after 2 to 4 weeks if necessary
  • Administration after meal at night
  • Swallow the capsule whole with a glass of water
  • Do not crush or chew the capsule

Interaction

  • Possible hypotensive effects with concurrent administration of other alfa1-adrenoceptor antagonists
  • No interactions with atenolol, enalapril, or nifedipine observed
  • Cimetidine may raise plasma levels while frusemide may lower plasma levels
  • Interactions with diclofenac and warfarin leading to increased elimination rate

Contraindications

  • Hypersensitivity to Tamsulosin hydrochloride
  • History of orthostatic hypotension
  • Severe hepatic insufficiency
  • Potential reduction in blood pressure leading to syncope

Side Effects

  • Dizziness
  • Abnormal ejaculation
  • Headache
  • Asthenia
  • Postural hypotension
  • Palpitations

Pregnancy & Lactation

  • Not recommended for use during pregnancy and lactation

Precautions & Warnings

  • Rare occurrence of transient postural symptoms during orthostatic provocation testing
  • Avoid use in patients with micturition syncope
  • Unknown effect on ability to drive or operate machines
  • Patients should be cautious of potential dizziness

Overdose Effects

  • Potential for acute hypotension
  • Cardiovascular support may be necessary
  • Monitoring of renal function
  • General supportive measures
  • Potential use of volume expanders and vasopressors
  • Emesis, gastric lavage, and activated charcoal may impede absorption

Storage Conditions

  • Store in a cool and dry place
  • Below 30°C
  • Protected from light

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