Tamsol 0.4 mg (Capsule (Modified Release))

Unit Price: ৳ 10.00 (2 x 10: ৳ 200.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Tamsulosin hydrochloride
Company Apex pharmaceuticals ltd

Indications

  • Treatment of functional symptoms of Benign Prostatic Hyperplasia (BPH)

Pharmacology

  • Tamsulosin is a selective alpha1 adrenoceptor blocking agent
  • Causes relaxation of smooth muscles in the bladder neck and prostate
  • Improves urine flow rate and reduces BPH symptoms
  • Highly bound to human plasma protein (94% to 99%)
  • Metabolized by cytochrome P450 enzymes in the liver
  • Elimination half-life in plasma ranges from five to fifteen hours

Dosage & Administration

  • 0.4 mg (one capsule) daily, to be taken after meal at night
  • Dose may be increased to 0.8 mg (two capsules) once daily if necessary
  • Should be swallowed whole with a glass of water
  • Avoid crunching or chewing the capsule

Interaction

  • Concurrent administration of alpha1-adrenoceptor antagonists may lead to hypotensive effects
  • No interactions seen with atenolol, enalapril, or nifedipine
  • Cimetidine may increase plasma levels of Tamsulosin
  • Diclofenac and warfarin may increase elimination rate of Tamsulosin

Contraindications

  • Hypersensitivity to Tamsulosin
  • History of orthostatic hypotension
  • Severe hepatic insufficiency
  • Caution in patients with micturition syncope
  • Reduction in blood pressure can occur, leading to syncope
  • Avoid situations where injury could result
  • Examination to exclude other conditions with similar symptoms as BPH
  • Digital rectal examination and PSA determination before and during treatment

Side Effects

  • Dizziness
  • Abnormal ejaculation
  • Headache
  • Asthenia
  • Postural hypotension
  • Palpitations

Pregnancy & Lactation

  • Not recommended for use during pregnancy and lactation

Precautions & Warnings

  • Rare occurrence of transient postural symptoms
  • Use in patients with micturition syncope not advised
  • Effects on ability to drive and operate machines
  • Dizziness can occur

Overdose Effects

  • Acute hypotension likely after overdose
  • Cardiovascular support should be given
  • Monitoring of renal function and general supportive measures
  • Emesis and gastric lavage in case of large overdose

Therapeutic Class

  • BPH/ Urinary retention/ Urinary incontinence

Storage Conditions

  • Store in a cool and dry place, below 30°C, protected from light

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