Ocin 5 IU/ml (IM/IV Injection)
5 IU ampoule: ৳ 15.00 (5 x 5: ৳ 375.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Oxytocin |
| Company | Opsonin pharma ltd |
Indications
- Induction of labor
- Stimulation of uterine contractions
- Prevent or treat secondary haemorrhage
- Prevent or treat adherent placenta
- Stimulate lactation
- Treatment of incomplete abortion
Description
- Synthetically prepared Ocin
- Identical to natural occurring hormone
- Causes uterine contractions
- Mimics contractions of normal labor
- Impedes uterine blood flow
- Increases amplitude and duration of contractions
- Leads to dilation and effacement of the cervix
- Stimulates lactating breast
- Has minimal cardiovascular and antidiuretic properties
Pharmacology
- Depends on the formation of actomyosin
- Promotes contractions by increasing intracellular Ca2+
- Activates myosin's light chain kinase
- Has specific receptors in the muscle lining of the uterus
- Receptor concentration increases greatly during pregnancy
Dosage & Administration
- Given by intravenous infusion
- Dosage range from 1-5 IU
- Initial administration at 1 mU per minute
- Dosage can be doubled every 30-45 minutes
- Intramuscular administration may lead to irregular response
- Dosage for different indications
Interactions
- Severe hypertension reported with prophylactic vasoconstrictor
- Cyclopropane anesthesia may modify cardiovascular effects
- Maternal sinus bradycardia noted with cyclopropane anesthesia
Contraindications
- Cephalo-pelvic disproportion
- Abnormal position of the child or skull
- Overdistention of the inferior segment of the uterus
- Severe toxaemia
- Hypertonic uterine dysfunction
- Foetal distress
- Cord presentation and prolapse
- Total placenta previa
- Vasa praevia
Side Effects
- Uterine hypertonicity
- Spasm
- Titanic contraction
- Rupture of the uterus
- Possibility of increased blood loss
- Severe water intoxication
- Nausea
- Vomiting
- Haemorrhage
- Cardiac arrhythmias
- Anaphylactic reaction
Pregnancy & Lactation
- Pregnancy category C
- Not known whether excreted in human milk
Precautions & Warnings
- Uterine sensitivity may vary widely
- Should be used with care
- Smallest effective dose must be determined
- Used only with adequate medical supervision
- Care when scars of the uterus and cervix uteri exist
Overdose Effects
- Violent uterine contractions
- Fetal bradycardia and arrhythmias
- Extensive laceration of soft tissues
- Uterine rupture
- Immediate discontinuation of infusion and induction of tocolysis
Therapeutic Class
- Drugs acting on the Uterus
Reconstitution
- Potency maintained for at least 24 hours
- Dilution with specific infusion fluids
- No precipitation of ingredients
Storage Conditions
- Store between 2 to 8°C
- Dark & frost free place
- Keep out of the reach of children