Oxyton 5 IU/ml (IM/IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Oxytocin |
| Company | Renata limited |
| Also available as |
Indications
- Induction of labor
- Stimulation of uterine contractions
- Prevention or treatment of secondary haemorrhage
- Adherent placenta treatment
- Stimulate lactation
- Treatment of incomplete abortion
Active Substance
Synthetically prepared Oxyton
Oxyton Function
Causes contractions of the uterus, mimicking normal labor contractions and impeding uterine blood flow, stimulates lactation
Technical Description
Identical to the natural occurring hormone from the posterior pituitary gland, minimal cardiovascular and antidiuretic properties
Pharmacology
Promotes contractions by increasing intracellular Ca2+ and activating myosin's light chain kinase
Dosage & Administration
- Intravenous infusion under control
- Dosage can be doubled every 30-45 minutes
- Threshold is generally below 10 mU per minute
- Intramuscular administration may lead to irregular response and symptoms of overdosage
- Specific dosages for different indications
Interaction
- Severe hypertension reported with prophylactic vasoconstrictor administration
- Cyclopropane anesthesia may modify cardiovascular effects
- Maternal bradycardia with abnormal rhythms noted with cyclopropane anesthesia
Contraindications
- Cephalo-pelvic disproportion
- Abnormal fetal position or skull position
- Overdistention of the uterus segment
- Severe toxaemia
- Hypertonic uterine dysfunction
- Foetal distress not imminent for delivery
- Cord presentation and prolapse
- Total placenta previa
- Vasa praevia
Side Effects
- Hypersensitivity may result in uterine hypertonicity
- Possibility of increased blood loss
- Severe water intoxication with convulsions and coma
- Nausea, vomiting, haemorrhage, cardiac arrhythmias
Pregnancy & Lactation
Pregnancy category C, not known if excreted in human milk
Precautions
- Uterine sensitivity may vary widely
- Smallest effective dose must be determined for each patient
- Should only be used with adequate medical supervision
- Used with care if uterine or cervical scars exist
Overdose Effects
May cause violent uterine contractions leading to fetal bradycardia and arrhythmias, extensive laceration of the soft tissues, uterine rupture and perhaps fetal or maternal death
Therapeutic Class
Drugs acting on the Uterus
Reconstitution
Does not lose potency for at least 24 hours when diluted with specific infusion fluids, can be directly injected into infusion line with certain fluids
Storage Conditions
Store between 2 to 8°C, in dark & frost free place, keep out of reach of children