DP-Done 10 mg (Tablet)

Unit Price: ৳ 2.00 (100's pack: ৳ 200.00)

Medicine Details

Category	Details
Generic	Domperidone maleate
Company	Central pharmaceuticals ltd
Also available as	Dp done 5 mg suspension

Title

DP-Done 10 mg Tablet

Description

Dopamine antagonist medication for treating dyspeptic symptom complex, acute nausea/vomiting, Parkinson's disease-induced nausea/vomiting, and speeding barium transit in radiological studies

Color Options

White

Dimensions

Standard tablet dimensions

Materials

Active ingredient: Domperidone
Excipients

Dosage

Adults: 10-20 mg, every 6-8 hours daily
Children: 2-4 ml suspension/10 kg body weight, every 6-8 hours daily

Administration

Oral: 15-30 minutes before meals
Rectal (suppositories): 30-60 mg every 4-8 hours

Function

Gastroprokinetic action
Restores normal motility and tone of upper gastrointestinal tract
Facilitates gastric emptying
Enhances antral and duodenal peristalsis
Regulates contraction of the pylorus
Increases esophageal peristalsis and lower esophageal sphincter pressure
Prevents regurgitation of gastric content

Reaction

Blocks dopamine receptors in Chemoreceptor Trigger Zone (CTZ) and stomach
Weak penetration across the blood-brain barrier
Almost no effect on dopaminergic receptors in the brain
Excludes psychotropic and neurologic side effects

Usability Features

Pregnancy & Lactation: Usage during first trimester justified by therapeutic benefit
Special Populations:
- Infants: Given with great caution and under medical supervision
- Liver Disorders: Use with caution
- Kidney Disorders: Dose adjustment in case of severe renal insufficiency
Overdose Effects: Drowsiness, disorientation, extrapyramidal reactions
Therapeutic Class:
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions: Below 30°C, Protected from light & moisture

Pharmacology

Dopamine antagonist primarily blocking dopamine receptors in CTZ and stomach

Interaction

Antagonistic Drugs: Anticholinergics
Antagonist for:
- Antacids
- Antisecretory drugs
Metabolic Pathway: CYP3A4
Inhibitors of CYP3A4:
- Azole antifungals
- Macrolide antibiotics
- HIV protease inhibitors
- Nefazodone
- etc.

Contraindications

Hypersensitivity to the drug
Neonates
Gastrointestinal hemorrhage
Mechanical obstruction or perforation
Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

Transient intestinal cramps
Extrapyramidal phenomena in rare cases
Increase in plasma prolactin level leading to neuroendocrinological phenomena
Rare allergic reactions (e.g., rash, urticaria)

Chemical Structure

Molecular Formula: C22H24ClN5O2
Image: URL to chemical structure image

Commonly Asked Questions

Usage for nausea and vomiting relief
Quick tips for usage

Precautions & Warnings

Increased risk of extra-pyramidal reactions in young children
Use with caution in hepatic impairment

Overdose Effects

Symptoms may include drowsiness, disorientation, and extrapyramidal reactions

Compound Summary

Molecular formula and chemical structure image provided

Common Questions about DP-Done 10 mg Tablet

Usage
Quick tips for usage

Pregnancy & Lactation

Animal Studies: Did not produce teratogenic effects
First Trimester Usage: Justified by anticipated therapeutic benefit
Risk of Malformations in Humans: No evidence reported
Breast Milk Excretion: 4 times lower than corresponding plasma concentrations