DP-Done 5 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 28.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Central pharmaceuticals ltd
Also available as
Dp done 10 mg tablet

Title

DP-Done 5 mg/5 ml Suspension

Categories

  • Medicine
  • Pharmaceutical

Description

Dopamine antagonist medication used to treat dyspeptic symptom complex, acute nausea and vomiting, Parkinson's disease, and speeding barium transit in radiological studies.

Color options

  • Clear liquid

Dimensions

Variable based on package size

Functions

  • Relieves dyspeptic symptoms
  • Reduces nausea and vomiting
  • Stimulates gastric motility
  • Enhances gastrointestinal peristalsis
  • Regulates pyloric contraction
  • Increases esophageal peristalsis
  • Regulates lower esophageal sphincter pressure

Materials

Active ingredient: Domperidone

Technical specifications

  • Dosage: 5 mg/5 ml
  • Maximum daily dose: 80 mg

Design elements

  • Suspension formulation
  • Oral administration

Usability features

  • Should be taken before meals
  • Possible rectal administration

Indications

  • Epigastric sense of fullness
  • Abdominal distension
  • Upper abdominal pain
  • Eructation
  • Flatulence
  • Early satiety
  • Nausea
  • Vomiting
  • Heartburn
  • Non-ulcer dyspepsia
  • Acute nausea and vomiting
  • Parkinson's disease-related nausea and vomiting
  • Radiological studies (speeding barium transit)

Pharmacology

Blocks dopamine receptors in Chemoreceptor Trigger Zone and stomach. Restores normal gastrointestinal motility and tone. Facilitates gastric emptying and enhances peristalsis. Increases esophageal peristalsis and lower esophageal sphincter pressure.

Dosage & Administration

  • Adult dose: 10-20 mg every 6-8 hours daily
  • Children's dose: 0.2-0.4 mg/kg body weight every 6-8 hours daily
  • Rectal administration for adults and children

Interaction

  • Antagonism with anticholinergic drugs
  • Decreased bioavailability with antacids and antisecretory drugs
  • Metabolic pathway through CYP3A4
  • Potential inhibition with CYP3A4 inhibitors
  • No potentiation of neuroleptics
  • Suppression of unwanted effects of dopaminergic agonists

Contraindications

  • Hypersensitivity to domperidone
  • Neonates
  • Gastrointestinal hemorrhage, obstruction, or perforation
  • Prolactin releasing pituitary tumor

Side Effects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena in children
  • Possible increase in plasma prolactin level
  • Rare allergic reactions

Pregnancy & Lactation

  • Use during first trimester justified by therapeutic benefit
  • No evidence of increased risk of malformations in humans
  • Excretion in breast milk
  • Lower concentration in breast milk compared to plasma

Precautions & Warnings

  • Use with caution in children and patients with hepatic impairment

Use in Special Populations

  • Caution in infants due to immature blood-brain barrier
  • Caution in patients with liver or kidney disorders

Overdose Effects

  • Drowsiness
  • Disorientation
  • Extrapyramidal reactions
  • Recommended management with activated charcoal
  • Anticholinergic drugs may be helpful

Therapeutic Class

Motility Stimulants, Dopamine Antagonist, Prokinetic drugs

Storage Conditions

Store below 30°C, protected from light and moisture

Chemical Structure

  • Molecular Formula: C22H24ClN5O2
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg

Common Questions

  • Usage: Relieves nausea, vomiting, and indigestion
  • Usage Tips:
    • Take before meals as prescribed
    • Avoid alcohol consumption
    • Possible side effect: dizziness and sleepiness
    • Consult a doctor if symptoms persist beyond 7 days

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