Natadrop 5% (Ophthalmic Suspension)

Indications

• Treatment of fungal blepharitis
• Treatment of conjunctivitis
• Treatment of keratitis caused by susceptible organisms including Fusarium solani keratitis

Pharmacology

• Tetraene polyene antibiotic derived from Streptomyces natalensis
• Binds to sterols in the fungal cell membrane
• Produces a change in membrane permeability
• Possesses in vitro activity against a variety of yeast and filamentous fungi

Dosage & Administration

• Initial dosage: 1 drop instilled in the conjunctival sac at 1-2 hours interval for fungal keratitis
• Frequency of application can usually be reduced to 1 drop 6-8 times daily after the first 3-4 days for fungal keratitis
• Pediatric use safety and effectiveness not established

Interaction

• May increase spread of fungal eye infection when used with topical corticosteroid

Contraindications

• Contraindicated in individuals with a history of hypersensitivity to any of its component

Side Effects

• Eye irritation
• Eye discomfort
• Eye edema
• Conjunctival chemosis
• Hyperemia

Pregnancy & Lactation

• Pregnancy category C
• Not known whether it can cause fetal harm when administered to pregnant women
• Caution should be exercised when administered to a nursing woman

Precautions & Warnings

• Do not touch dropper tip to any surface
• Patient advised not to wear contact lenses if they have signs and symptoms of fungal blepharitis, conjunctivitis, and keratitis
• Therapy continuation based on clinical re-evaluation

Therapeutic Class

• Ophthalmic antibacterial drugs

Storage Conditions

• Store in a cool and dry place
• Protect from light
• Do not freeze
• Do not use for longer than one month after first opening of the bottle

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