Nicin 5% (Ophthalmic Suspension)
5 ml drop: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Natamycin |
| Company | Nipa pharmaceuticals ltd |
Indications
- Treatment of fungal blepharitis
- Treatment of conjunctivitis
- Treatment of keratitis
- Caused by susceptible organisms including Fusarium solani
Pharmacology
- Containing natamycin
- Tetraene polyene antibiotic
- Derived from Streptomyces natalensis
- Exerts antifungal effects by binding to sterols in the fungal cell membrane
- Produces change in membrane permeability
- Possesses in vitro activity against yeast and filamentous fungi including Candida, Aspergillus, Cephalosporium, Fusarium, and Penicillium
- Predominantly fungicidal
- Topical administration produces effective concentration within the corneal stroma
- Not effective in intraocular fluid
Dosage & Administration
- Initial dosage: 1 drop instilled in the conjunctival sac at 1-2 hours interval
- Frequency of application can be reduced to 1 drop 6-8 times daily after the first 3-4 days
- Therapy duration: 14 to 21 days
- Pediatric use safety and effectiveness not established
Interaction
- May increase spread of fungal eye infection
- When used with topical corticosteroid
Contraindications
- Contraindicated in individuals with history of hypersensitivity to any component
Side Effects
- Eye irritation
- Eye discomfort
- Eye edema
- Conjunctival chemosis
- Hyperemia
Pregnancy & Lactation
- Pregnancy category C
- Animal reproduction studies not conducted
- Potential fetal harm and impact on reproduction capacity unknown
- Administer to pregnant women only if clearly needed
- Excretion in human milk unknown
- Caution should be exercised when administered to nursing women
Precautions & Warnings
- Do not touch dropper tip to any surface
- Patient advised not to wear contact lenses if signs and symptoms present
- Failure of improvement suggests infection by non-susceptible microorganism
- Continuation of therapy should be based on clinical re-evaluation and additional laboratory studies
- Adherence of the suspension to areas of epithelial ulceration or retention in the fornices occurs regularly
Therapeutic Class
- Ophthalmic antibacterial drugs
Storage Conditions
- Store in a cool and dry place
- Protect from light
- Do not freeze
- Do not use for longer than one month after first opening of the bottle