Dysnov 5 mg/5 ml (Oral Suspension)

100 ml bottle: ৳ 40.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Unimed unihealth pharmaceuticals ltd
Also available as
Dysnov 10 mg tablet Dysnov 5 mg pediatric drop

Indications

  • Dyspeptic symptom complex
  • Delayed gastric emptying
  • Gastroesophageal reflux
  • Esophagitis
  • Acute nausea and vomiting
  • Functional nausea and vomiting
  • Nausea and vomiting induced by radiotherapy
  • Nausea and vomiting induced by drug therapy
  • Nausea and vomiting in migraine
  • Parkinson's disease
  • Speeding barium transit in radiological studies

Pharmacology

  • Dopamine antagonist
  • Blocks dopamine receptors in Chemoreceptor Trigger Zone (CTZ) and stomach
  • Gastroprokinetic action
  • Restores normal motility and tone of upper gastrointestinal tract
  • Facilitates gastric emptying
  • Enhances antral and duodenal peristalsis
  • Regulates contraction of the pylorus
  • Increases esophageal peristalsis
  • Regulates lower esophageal sphincter pressure

Dosage & Administration

  • Should be taken 15-30 minutes before meals
  • Usual recommended oral dose for adults: 10-20 mg every 6-8 hours daily
  • Maximum recommended daily dose for adults: 80 mg
  • Dosing for children based on body weight
  • Administration by rectum in suppositories
  • Maximum period of treatment is 12 weeks

Interaction

  • Antagonizes antidyspeptic effect of anticholinergic drugs
  • Lower oral bioavailability with simultaneous antacids and antisecretory drugs administration
  • Metabolic pathway through CYP3A4
  • Concomitant use of CYP3A4 inhibitors may increase plasma levels of domperidone
  • Potential influence on absorption of concomitantly orally administered drugs
  • Does not potentiate the action of neuroleptics
  • Suppresses unwanted peripheral effects of dopaminergic agonists

Contraindications

  • Known hypersensitivity to domperidone
  • Neonates
  • Gastrointestinal hemorrhage
  • Mechanical obstruction
  • Perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena
  • Increase in plasma prolactin level
  • Rare allergic reactions like rash and urticaria

Pregnancy & Lactation

  • Use during first trimester justified by therapeutic benefit
  • No evidence of increased risk of malformations in humans
  • Excretion in breast milk
  • Not recommended for nursing mothers unless benefits outweigh potential risk

Precautions & Warnings

  • Caution in the case of children due to risk of extra-pyramidal reactions
  • Caution in patients with hepatic impairment

Use in Special Populations

  • Caution in infants due to incomplete development of metabolic and blood-brain barrier functions
  • Caution in liver disorders
  • Caution in severe renal insufficiency

Overdose Effects

  • Symptoms: drowsiness, disorientation, extrapyramidal reactions
  • Administration of activated charcoal recommended
  • Anticholinergic drugs or antihistamines may be helpful in controlling extrapyramidal reactions

Therapeutic Class

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

Storage Conditions

  • Store below 30°C
  • Protected from light and moisture
  • Keep out of children's reach

Chemical Structure

  • Molecular Formula: C22H24ClN5O2

Common Questions about Dysnov 5 mg/5 ml Suspension

  • Used for treating nausea and vomiting
  • Helps relieve nausea, vomiting, and indigestion
  • Caution in activities requiring mental focus
  • Avoid consuming alcohol
  • Possible side effect: dry mouth
  • Consult a doctor if certain symptoms persist

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