Edone 5 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 31.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Zenith pharmaceuticals ltd
Also available as
Edone 10 mg tablet

Type of Product

Medication

Brand Name

Edone 5 mg/5 ml Suspension

Therapeutic Class

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

Indications

  • Dyspeptic symptom complex
  • Acute nausea and vomiting
  • Parkinson's disease
  • Radiological studies

Pharmacology

Domperidone is a dopamine antagonist that blocks dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and stomach.

Dosage & Administration

  • General Dosage:
    • Adults: 10-20 mg every 6-8 hours daily
    • Children: 2-4 ml/10 kg body weight every 6-8 hours daily
  • Specific Conditions:
    • Dyspeptic Symptom: 10-20 mg every 6-8 hours daily
    • Acute and Sub-Acute Conditions: 20 mg every 6-8 hours daily
    • Rectal Administration:
      • Adults (including elderly): 30-60 mg every 4-8 hours
      • Children: Max daily dose of 30 mg for 10-25 kg weight

Interaction

  • Concomitant Administration: Anticholinergic drugs may antagonize the antidyspeptic effect.
  • Drugs to Avoid:
    • Antacids
    • Antisecretory drugs
    • CYP3A4 inhibitors
  • Compatible Drugs:
    • Neuroleptics
    • Dopaminergic agonists

Contraindications

  • Known hypersensitivity to the drug
  • Neonates
  • Gastrointestinal hemorrhage
  • Mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Extrapyramidal phenomena
  • Hyperprolactinaemia
  • Rare allergic reactions

Pregnancy & Lactation

  • Animal Studies: Doses up to 160 mg/kg/day did not produce teratogenic effects.
  • Human Use: Use during the first trimester if justified by therapeutic benefit. Caution in lactating mothers.

Precautions & Warnings

  • Caution in children due to risk of extrapyramidal reactions
  • Caution in hepatic impairment

Use in Special Populations

  • Caution in infants
  • Caution in liver disorders
  • Caution in kidney disorders

Overdose Effects

Symptoms may include drowsiness, disorientation, and extrapyramidal reactions. Management with activated charcoal and close observation.

Storage Conditions

Store below 30°C, protected from light & moisture.

Chemical Structure

  • Molecular Formula: C22H24ClN5O2
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg

Common Uses

  • First Use: Treat nausea and vomiting
  • Quick Tips:
    • Helps relieve nausea, vomiting, and indigestion
    • Should be taken before meals as per doctor's prescription
    • May cause dizziness and sleepiness. Caution with driving or tasks requiring focus
    • Avoid alcohol consumption
    • Dry mouth may occur as a side effect
    • Consult a doctor if diarrhea, fever, or stomach pain persist
    • Do not use for longer than 7 days without consulting a doctor

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