Dexcor 0.5 mg (Tablet)
Unit Price: ৳ 1.10 (20 x 10: ৳ 220.00)
Strip Price: ৳ 11.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Dexamethasone |
| Company | Aci limited |
| Also available as |
Indications
- Severe allergic conditions in asthma, dermatitis, rhinitis, etc.
- Collagen diseases like lupus erythematosus and rheumatoid arthritis
- Treatment of various dermatologic diseases
- Management of endocrine disorders
- Gastrointestinal diseases such as enteritis and colitis
- Management of hematologic disorders like anemia and thrombocytopenic purpura
- Treatment of neoplastic diseases like leukemias and lymphomas
- Management of nervous system conditions
- Ophthalmic diseases such as temporal arteritis and uveitis
- Renal diseases like idiopathic nephrotic syndrome
- Respiratory diseases including pulmonary tuberculosis and sarcoidosis
- Rheumatic disorders like gouty arthritis and rheumatoid arthritis
- Diagnostic testing of adrenocortical hyperfunction and tuberculous meningitis
- Control of cerebral edema associated with brain tumors
- Induction of diuresis or remission of proteinuria
- Treatment of acute exacerbations of multiple sclerosis
- Management of various pediatric conditions like juvenile rheumatoid arthritis
- Treatment for musculoskeletal disorders like dermatomyositis and polymyositis
- Control of systemic lupus erythematosus and related conditions
- Management of trichinosis with neurologic or myocardial involvement
- Adjunctive therapy for acute rheumatic carditis and ankylosing spondylitis
- Usability as an emergency treatment for anaphylaxis and acute severe asthma
Pharmacology
- Synthetic glucocorticoid with anti-inflammatory properties
- Inhibits leukocyte migration
- Reverses increased capillary permeability
- Suppresses normal immune response
Dosage & Administration
- Oral dosages in adult patients range from 1 mg to 10 mg
- Oral dosages in children range from 0.03-0.20 mg/kg body weight
- Higher dosages may be temporarily required in some patients
- Guidelines for short dexamethasone suppression test
- Intravenous, intramuscular, and local injection administration
- Dosing guidelines for systemic therapy in adults
- Recommended local therapy doses for specific conditions
Interaction
- Enhanced potassium loss with diuretics and cardiac glycosides
- Impaired glucose tolerance with antidiabetic drugs
- Increased risk of gastrointestinal ulceration with NSAIDs
- Alteration of oral anticoagulant need
- Decreased efficacy with liver enzyme inducing drugs
- Caution needed when co-administered with salicylates and antacids
Contraindications
- Gastric and duodenal ulcers
- Systemic and ophthalmic fungal infections
- Viral infections like varicella and herpes genitalis
- Glaucoma
- Hypersensitivity to corticosteroids
Side Effects
- Adverse reactions associated with prolonged systemic glucocorticoid therapy
- Endocrine and metabolic disturbances like Cushing-like syndrome
- Fluid and electrolyte disturbances including sodium retention and potassium loss
- Musculo-skeletal effects such as myopathy and osteoporosis
- Gastro-intestinal effects like ulceration and perforation
- Dermatological effects including impaired wound healing and skin atrophy
- Central Nervous System effects ranging from euphoria to psychotic manifestations
- Ophthalmic effects like glaucoma and increased intraocular pressure
- Immunosuppressive effects leading to increased susceptibility to infections
Pregnancy & Lactation
- Pregnancy Category C
- Limited studies in pregnant women
- Glucocorticoids appear in breast milk
- Advice against breastfeeding for mothers on high dosages
Precautions & Warnings
- Use the lowest possible dose to control the condition
- Caution in patients with cardio-renal conditions
- Minimize drug-induced secondary adrenocortical insufficiency
- Special consideration for patients at risk of osteoporosis
- Awareness of acute myopathy with high doses in specific patient populations
Use in Special Populations
- Titration to the lowest effective dose in pediatric patients
Overdose Effects
- Unlikely overdosage
- Treatment by supportive and symptomatic therapy
Storage Conditions
- Tablet: Store in a cool & dry place, protected from light & moisture
- Injection: Store below 30°C, protected from light