Metadaxan 0.5 mg (Tablet)

Unit Price: ৳ 1.00 (10 x 10: ৳ 100.00)

Strip Price: ৳ 10.00

Medicine Details

Category	Details
Generic	Dexamethasone
Company	Incepta pharmaceuticals ltd
Also available as	Metadaxan 5 mg injection

Title

Dexamethasone Tablet

Description

Dexamethasone is a synthetic glucocorticoid used to treat various conditions such as allergic states, collagen diseases, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematologic disorders, neoplastic diseases, nervous system disorders, ophthalmic diseases, renal diseases, respiratory diseases, rheumatic disorders, and more.

Dimensions

Varies by packaging size

Color options

White
Off-white

Functions

Anti-inflammatory
Immunosuppressant
Glucocorticoid

Materials

Active ingredient: Dexamethasone
Excipients: Vary by dosage form

Technical specifications

Dosage Forms:
- Tablet
- Injection
Dosage Range: 1-10 mg for adults, 0.03-0.20 mg/kg for children
Administration: Oral, intravenous, intramuscular, local injection
Storage Conditions: Cool, dry place; protect from light and moisture
Pregnancy Category: Category C
Pediatric Use: Titrate to lowest effective dose
Overdose Treatment: Supportive and symptomatic therapy

Design elements

Circular tablet shape
Embossed logo

Usability features

Effective for short-term and long-term therapy
Multiple administration options

Indications

Severe allergic conditions
Collagen diseases like lupus erythematosus and rheumatoid arthritis
Dermatologic diseases such as pemphigus and erythema multiforme
Endocrine disorders like adrenocortical insufficiency
Gastrointestinal diseases like ulcerative colitis
Hematologic disorders like anemia and thrombocytopenic purpura
Neoplastic diseases including leukemias and lymphomas
Nervous system disorders like multiple sclerosis
Ophthalmic diseases including uveitis
Renal diseases inducing diuresis or remission of proteinuria
Respiratory diseases like pulmonary tuberculosis and sarcoidosis
Rheumatic disorders like rheumatoid arthritis and gouty arthritis
Miscellaneous conditions like diagnostic testing and trichinosis

Interaction

Potential interaction with diuretics and cardiac glycosides
May impair glucose tolerance and interact with anti-diabetic drugs
Increased incidence of gastrointestinal ulceration with non-steroidal anti-inflammatory drugs
Potential alteration in the need for oral anti-coagulants
May be less effective when used with liver enzyme-inducing drugs
Caution needed when concomitantly given with salicylates and antacids

Contraindications

Gastric and duodenal ulcers
Systemic and ophthalmic fungal infections
Viral infections like varicella and herpes genitalis
Glaucoma
Hypersensitivity to corticosteroids

Side effects

Endocrine:
- Cushing-like syndrome
- Hirsutism
- Menstrual irregularities
Fluid & electrolyte:
- Sodium and fluid retention
- Hypokalaemic alkalosis
Musculo-skeletal:
- Myopathy
- Osteoporosis
Gastro-intestinal:
- Ulceration
- Perforation
- Haemorrhage
Dermatological:
- Impaired wound healing
- Skin atrophy
Central Nervous System:
- Psychic disturbances
- Pseudotumor cerebri
Ophthalmic:
- Glaucoma
- Increased intraocular pressure
Immunosuppressive:
- Increased susceptibility to infections

Pregnancy and lactation

Pregnancy: Category C; potential benefit justifies potential risk to fetus
Lactation: Glucocorticoids appear in breast milk; caution advised

Precautions and warnings

General: Use lowest possible dose to control the condition
Cardio-renal: Use with caution in patients with heart failure, hypertension, or renal insufficiency
Endocrine: Minimize secondary adrenocortical insufficiency with gradual dosage reduction
Gastrointestinal: Use with caution in peptic ulcers and colitis
Musculoskeletal: Consider osteoporosis risk before initiating therapy
Neuro-psychiatric: Be vigilant for acute myopathy and psychiatric disturbances