Emidom 5 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 28.11

Medicine Details

Category Details
Generic Domperidone maleate
Company Somatec pharmaceuticals ltd
Also available as
Emidom 10 mg tablet

Indications

  • Dyspeptic symptom complex
  • Delayed gastric emptying
  • Gastroesophageal reflux
  • Esophagitis
  • Acute nausea and vomiting
  • Functional nausea and vomiting
  • Nausea and vomiting induced by radiotherapy
  • Nausea and vomiting induced by drug therapy
  • Nausea and vomiting induced in migraine
  • Parkinson's disease
  • Radiological studies

Pharmacology

  • Dopamine antagonist
  • Block dopamine receptors in Chemoreceptor Trigger Zone (CTZ) and stomach
  • Gastroprokinetic action
  • Restores normal motility and tone of upper gastrointestinal tract
  • Facilitates gastric emptying
  • Enhances antral and duodenal peristalsis
  • Regulates contraction of the pylorus
  • Increases esophageal peristalsis
  • Regulates lower esophageal sphincter pressure

Dosage & Administration

  • Should be taken 15-30 minutes before meals
  • Usual recommended oral dose for adults: 10-20 mg every 6-8 hours daily
  • Maximum dose for adults: 80 mg daily
  • Usual recommended oral dose for children
  • Maximum period of treatment for acute nausea and vomiting: 12 weeks
  • Rectal administration for adults and children
  • Maximum daily dose rectally in children: 30 mg

Interaction

  • Antagonizes antidyspeptic effect of domperidone with anticholinergic drugs
  • Lower oral bioavailability with antacids and antisecretory drugs
  • Main metabolic pathway through CYP3A4
  • Concomitant use of CYP3A4 inhibitors may increase plasma levels of domperidone

Contraindications

  • Known hypersensitivity to the drug
  • Neonates
  • Gastrointestinal hemorrhage
  • Mechanical obstruction
  • Perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena
  • Increase in plasma prolactin level
  • Hyperprolactinaemia may give rise to neuroendocrinological phenomena
  • Rare allergic reactions (rash, urticaria)

Pregnancy & Lactation

  • Should only be used during the first trimester of pregnancy if justified by therapeutic benefit
  • No evidence of increase in risk of malformations in humans
  • Excreted in breast milk of lactating rats
  • Domperidone concentrations in breast milk are 4 times lower than corresponding plasma concentrations
  • Nursing not recommended unless expected benefits outweigh potential risk
  • Does not affect mental alertness

Precautions & Warnings

  • Increased risk of extra-pyramidal reactions in young children
  • Caution in patients with hepatic impairment

Use in Special Populations

  • Caution in infants due to incomplete blood-brain barrier development
  • Caution in liver disorders
  • Caution in severe renal insufficiency

Overdose Effects

  • Symptoms may include drowsiness, disorientation, extrapyramidal reactions
  • Administer activated charcoal and observe the patients

Therapeutic Class

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

Storage Conditions

  • Store below 30°C
  • Protected from light & moisture
  • Keep out of children's reach

Chemical Structure

  • Molecular Formula: C22H24ClN5O2

Common Questions

  • Used to treat nausea and vomiting
  • Helps relieve indigestion
  • May cause dizziness and sleepiness
  • Should be taken before meals as per doctor's prescription
  • Avoid consuming alcohol while taking the suspension
  • May cause dry mouth and diarrhea
  • Not recommended for longer than 7 days without consulting a doctor

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