Dexacol 0.1%+0.5% (Ophthalmic Solution)

5 ml drop: ৳ 70.21

Medicine Details

Category Details
Generic Dexamethasone chloramphenicol
Company Osl pharma limited

Indications

  • Treatment of acute purulent conjunctivitis
  • Treatment of corneal ulcer
  • Treatment of keratitis disciformis
  • Treatment of post-herpetic keratitis
  • Treatment of allergic conjunctivitis
  • Treatment of allergic blepharitis
  • Treatment of iritis
  • Treatment of uveitis
  • Treatment of corneal injury from chemical radiation or thermal burns
  • Treatment of otitis externa
  • Treatment of otitis media
  • Treatment of chronic suppurative otitis media

Pharmacology

  • Dexamethasone has anti-inflammatory action
  • Dexamethasone has anti-allergic action
  • Chloramphenicol is a broad spectrum bacteriostatic antibiotic
  • Chloramphenicol is active against gram-negative organisms
  • Chloramphenicol is active against gram-positive organisms
  • Chloramphenicol inhibits bacterial protein synthesis

Dosage & Administration

  • Recommended dosage regimen for bacterial conjunctivitis
  • Recommended dosage regimen for corneal ulcers
  • Recommended dosage regimen for otitis externa
  • Recommended dosage regimen for otitis media
  • Care should be taken not to discontinue therapy prematurely

Interaction

  • Potential interaction with anticoagulants
  • Inhibition of Chloramphenicol action by Phenobarbital
  • Reduced efficacy of Dexamethasone with phenytoin
  • Reduced efficacy of Dexamethasone with phenobarbitone
  • Reduced efficacy of Dexamethasone with ephedrine
  • Reduced efficacy of Dexamethasone with rifampicin

Contraindications

  • Contraindicated in epithelial herpes simplex cornealis
  • Contraindicated in fungal infections of the eye
  • Contraindicated in viral infections of the eye
  • Contraindicated in tuberculous infections of the eye
  • Contraindicated in glaucoma
  • Contraindicated in myelosuppression during previous exposure to Chloramphenicol
  • Contraindicated in hypersensitivity to Chloramphenicol & Dexamethasone

Side Effects

  • Transient ocular burning or discomfort
  • Stinging
  • Redness
  • Itching
  • Conjunctivitis
  • Foreign body sensation
  • Photophobia
  • Blurred vision
  • Dryness
  • Eye pain
  • Allergic sensitization
  • Elevation of intraocular pressure
  • Development of glaucoma
  • Optic nerve damage
  • Posterior subcapsular cataract formation

Pregnancy & Lactation

  • Use during pregnancy if potential benefit justifies potential risk
  • Caution when administered to nursing mothers

Precautions & Warnings

  • Consideration of persistent fungal infections of the cornea
  • Monitoring of intraocular pressure
  • Possibility of posterior subcapsular cataract formation
  • Possibility of glaucoma with optic nerve damage
  • Possibility of overgrowth of non-susceptible organisms

Therapeutic Class

  • Ophthalmic steroid - antibiotic combined preparations

Storage Conditions

  • Keep in cool and dry place
  • Keep away from light
  • Keep out of the reach of children
  • Do not use after 30 days of first opening

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