Nicodex 0.1%+0.5% (Ophthalmic Solution)

5 ml drop: ৳ 60.00

Medicine Details

Category Details
Generic Dexamethasone chloramphenicol
Company Rephco pharmaceuticals ltd

Indications

  • Acute purulent conjunctivitis
  • Inflammation of corneal layers
  • Corneal ulceration
  • Keratitis disciformis
  • Post-herpetic keratitis
  • Allergic conjunctivitis
  • Allergic blepharitis
  • Acute and chronic iritis
  • Chronic anterior uveitis
  • Corneal injury from chemical/radiation/thermal burns

Pharmacology

  • Dexamethasone: glucocorticoid with anti-inflammatory action
  • Chloramphenicol: broad-spectrum bacteriostatic antibiotic

Dosage & Administration

  • Bacterial Conjunctivitis: 1-2 drops every 2 hours for 2 days
  • Corneal Ulcers: 2 drops every 15 minutes for 6 hours
  • Otitis Externa: 2-3 drops every 2-3 hours initially

Interaction

  • Chloramphenicol absorption with anticoagulants
  • Inhibition of Chloramphenicol with Phenobarbital
  • Reduced efficacy of Dexamethasone with phenytoin/phenobarbitone/ephedrine/rifampicin

Contraindications

  • Epithelial herpes simplex cornealis
  • Fungal/viral/tuberculous infections of the eye
  • Glaucoma
  • Myelosuppression during previous Chloramphenicol exposure
  • Hypersensitivity to Chloramphenicol & Dexamethasone Phosphate

Side Effects

  • Transient ocular burning/discomfort
  • Stinging, redness, itching, conjunctivitis
  • Photophobia, blurred vision, dryness, eye pain
  • Allergic sensitization, elevation of intraocular pressure, glaucoma
  • Optic nerve damage, posterior subcapsular cataract formation

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Caution when used during pregnancy/nursing

Precautions & Warnings

  • Risk of persistent fungal infections
  • Prolonged use may result in cataract formation and glaucoma
  • Intraocular pressure monitoring needed
  • Risk of overgrowth of non-susceptible organisms
  • Discontinue if new infections appear, alternate therapy needed

Therapeutic Class

  • Ophthalmic steroid-antibiotic combined preparations

Storage Conditions

  • Keep in a cool, dry place away from light
  • Keep out of the reach of children
  • Do not use after 30 days of first opening

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