Cinarex D 0.1%+0.3% (Ophthalmic Solution)

Indications

• Treatment of steroid responsive inflammatory ocular conditions
• Chronic anterior uveitis
• Corneal injury from chemical radiation or thermal burns
• Penetration of foreign bodies
• Combination use with anti-infective component

Pharmacology

• Bactericidal activity of Tobramycin
• Inhibition of normal protein synthesis in susceptible bacteria
• Inhibition of phospholipase A2 by Dexamethasone
• Inhibition of chemo-tactic infiltration of neutrophils

Dosage & Administration

• Eye Drops: 3-5 times per day
• Initial dosage increase for first 24 to 48 hours
• Eye Ointment: 3-4 times per day
• Pediatric Use: Not established below age of 2 years

Interaction

• No specific interaction studies performed
• Allow 10 minutes interval with other topical ophthalmic medicines

Contraindications

• Epithelial herpes simplex keratitis
• Vaccinia
• Varicella
• Mycobacterial infection of the eye
• Hypersensitivity to any component

Side Effects

• Hypersensitivity
• Localized ocular toxicity
• Elevation of intraocular pressure
• Possible development of glaucoma
• Infrequent optic nerve damage
• Posterior subcapsular cataract formation
• Delayed wound healing

Pregnancy & Lactation

• Pregnancy: Use if potential benefit justifies the potent risk to fetus
• Nursing Mothers: Caution if administered to a nursing woman

Precautions & Warnings

• Consider possibility of fungal infections of the cornea after long-term steroid dosing
• Prolonged use may result in overgrowth of non-susceptible organisms
• Cross-sensitivity to other aminoglycoside antibiotics may occur

Overdose Effects

• No known local administration overdose
• Specific measures to reduce resorption in case of accidental oral intake
• No specific antidote

Therapeutic Class

• Ophthalmic steroid - antibiotic combined preparations

Storage Conditions

• Store at room temperature
• Close the bottle immediately after use
• Do not use for longer than one month after opening

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