Cotadex 0.1%+0.3% (Ophthalmic Solution)

Indications

• Steroid responsive inflammatory ocular conditions
• Chronic anterior uveitis
• Corneal injury from chemical radiation
• Penetration of foreign bodies

Pharmacology

• Bactericidal activity of Tobramycin
• Inhibition of normal protein synthesis
• Inhibition of phospholipase A2 by Dexamethasone

Dosage & Administration

• Insert 1 drop into the conjunctival sac 3-5 times per day for Eye Drops
• Apply a small amount into the conjunctival sac 3-4 times per day for Eye Ointment

Interaction

• No specific interaction studies conducted with Cotadex eye drops

Contraindications

• Epithelial herpes simplex keratitis
• Mycobacterial infection of the eye
• Hypersensitivity to any component of the medication

Side Effects

• Hypersensitivity
• Localized ocular toxicity
• Elevation of intraocular pressure
• Posterior subcapsular cataract formation
• Delayed wound healing

Pregnancy & Lactation

• Use during pregnancy only if potential benefit justifies risk to the fetus
• Caution when administered to a nursing woman

Precautions & Warnings

• Possibility of fungal infections of the cornea
• Prolonged use may result in overgrowth of non-susceptible organisms
• Consider cross-sensitivity to other aminoglycoside antibiotics

Overdose Effects

• Overdose through local administration not known
• Specific measures to reduce resorption in case of accidental oral intake

Therapeutic Class

• Ophthalmic steroid-antibiotic combined preparations

Storage Conditions

• Store at room temperature
• Close the bottle immediately after use
• Do not use for longer than one month after opening the bottle

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