Dexagen T 0.1%+0.3% (Ophthalmic Solution)

Indications

• Steroid responsive inflammatory ocular conditions
• Chronic anterior uveitis
• Corneal injury from chemical radiation or thermal burns
• Penetration of foreign bodies
• Combination with anti-infective component

Pharmacology

• Bactericidal activity of Tobramycin
• Inhibition of normal protein synthesis in susceptible bacteria
• Inhibition of protein synthesis by Dexamethasone
• Inhibition of phospholipase A2 by Dexamethasone
• Inhibition of chemo-tactic infiltration of neutrophils by Dexamethasone

Dosage & Administration

• Insert 1 drop into the conjunctival sac 3-5 times per day
• Increase dosage to 1 drop every 2 hours for initial 24 to 48 hours
• Apply eye ointment into the conjunctival sac 3-4 times per day
• Pediatric use not established for patients below 2 years

Interaction

• No specific interaction studies performed with Dexagen T eye drops
• Allow 10 minutes interval with other topical ophthalmic medicines

Contraindications

• Epithelial herpes simplex keratitis
• Vaccinia and varicella
• Mycobacterial infection of the eye
• Hypersensitivity to any component of the medication

Side Effects

• Hypersensitivity and localized ocular toxicity
• Elevation of intraocular pressure with possible development of glaucoma
• Optic nerve damage
• Posterior sub capsular cataract formation
• Delayed wound healing

Pregnancy & Lactation

• Lack of adequate and well-controlled studies in pregnant women
• Use during pregnancy if potential benefit justifies risk to the fetus
• Unknown systemic absorption to produce detectable quantities in human milk
• Caution during nursing period

Precautions & Warnings

• Possibility of fungal infections of the cornea after long-term steroid dosing
• Prolonged use may result in overgrowth of non-susceptible organisms
• Consider super infection and initiate appropriate therapy
• Cross-sensitivity to other aminoglycoside antibiotics may occur

Overdose Effects

• Overdose through local administration not known
• Specific measures to reduce resorption in case of accidental oral intake

Therapeutic Class

• Ophthalmic steroid - antibiotic combined preparations

Storage Conditions

• Room temperature storage
• Close the bottle immediately after use
• Do not use for longer than one month after opening

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