Tobidex 0.1%+0.3% (Ophthalmic Solution)

Indications

• Steroid responsive inflammatory ocular conditions
• Chronic anterior uveities
• Corneal injury from chemical radiation or thermal burns
• Penetration of foreign bodies
• Combination with an anti-infective component

Pharmacology

• Bactericidal activity of Tobramycin
• Inhibition of normal protein synthesis in susceptible bacteria
• Action on ribosome causing bacterial misreading of messenger RNA
• Inhibition of phospholipase A2 by Dexamethasone
• Inhibition of chemo-tactic infiltration of neutrophils into the site of inflammation by Dexamethasone

Dosage & Administration

• Eye Drops: Insert 1 drop into the conjunctival sac 3-5 times per day
• Increase dosage to 1 drop every 2 hours during initial 24 to 48 hours
• Eye Ointment: Apply a small amount into the conjunctival sac 3-4 times per day
• Pediatric Use: Safety and effectiveness in pediatric patients below the age of 2 years not established

Interaction

• No specific interaction studies with Tobidex eye drops
• Allow interval of 10 minutes between successive applications with other topical ophthalmic medicines

Contraindications

• Epithelial herpes simplex keratitis (dendritic keratitis)
• Vaccinia
• Varicella
• Mycobacterial infection of the eye
• Hypersensitivity to any component of the medication

Side Effects

• Hypersensitivity and localized ocular toxicity including lid itching, swelling and conjunctival erythema
• Elevation of intraocular pressure with possible development of glaucoma
• Infrequent optic nerve damage
• Posterior sub capsular cataract formation
• Delayed wound healing

Pregnancy & Lactation

• Pregnancy: Use only if potential benefit justifies potent risk to the fetus
• Nursing Mothers: Caution should be exercised when administered to a nursing woman

Precautions & Warnings

• Consideration of fungal infections of the cornea after long-term steroid dosing
• Prolonged use may result in overgrowth of non-susceptible organisms, including fungi
• Cross-sensitivity to other aminoglycoside antibiotics may occur
• Discontinue use and institute appropriate therapy if hypersensitivity develops

Overdose Effects

• Overdose through local administration not known
• Specific measures to reduce resorption should be taken in case of accidental oral intake
• No specific antidote

Therapeutic Class

• Ophthalmic steroid - antibiotic combined preparations

Storage Conditions

• Store at room temperature
• Close the bottle immediately after use
• Do not use for longer than one month after opening the bottle

Related Brands

• Tobidex 0.1%+0.3% (Ophthalmic Ointment) - gaco-pharmaceuticals-ltd
• Tomycin-D 0.1%+0.3% (Ophthalmic Solution) - ibn-sina-pharmaceuticals-ltd
• Tomycin-D 0.1%+0.3% (Ophthalmic Ointment) - ibn-sina-pharmaceuticals-ltd
• Dexagen T 0.1%+0.3% (Ophthalmic Ointment) - general-pharmaceuticals-ltd
• Infladex-TN 0.1%+0.3% (Ophthalmic Solution) - biopharma-limited