Neopred 0.05% (Ophthalmic Emulsion)

5 ml drop: ৳ 230.00

Medicine Details

Category Details
Generic Difluprednate
Company Aristopharma ltd

Indications

  • Treatment of inflammation and pain associated with ocular surgery
  • Treatment of uveitis
  • Treatment of pseudophakic cystoid macular edema (CME)
  • Treatment of ocular surface diseases e.g. blepharitis & corneal inflammation

Pharmacology

  • Corticosteroids inhibit inflammatory response
  • Inhibition of edema, fibrin deposition, capillary dilation
  • Inhibition of leukocyte migration, capillary proliferation
  • Inhibition of fibroblast proliferation, collagen deposition
  • Inhibition of scar formation associated with inflammation
  • Induction of phospholipase A2 inhibitory proteins
  • Control of biosynthesis of inflammatory mediators
  • Structurally similar to other corticosteroids

Dosage & Administration

  • Initial dosage: 1 drop into the conjunctival sac of the affected eye 4 times daily
  • Post-operative period: 4 times daily for 2 weeks, followed by tapering
  • Anterior uveitis: 4 times daily for 14 days, followed by tapering
  • Blepharitis: 2 times daily for 1 week, then once daily for 1 week
  • Pseudophakic cystoid macular edema: 2 times daily

Interaction

  • Specific drug interaction studies not conducted

Contraindications

  • Contraindicated in active viral diseases of the cornea and conjunctiva
  • Contraindicated in mycobacterial infection of the eye
  • Contraindicated in fungal diseases of ocular structures

Side Effects

  • Elevated intraocular pressure
  • Visual acuity and field defects
  • Posterior subcapsular cataract formation
  • Secondary ocular infection from pathogens including herpes simplex
  • Perforation of the globe
  • Corneal edema
  • Ciliary and conjunctival hyperemia
  • Eye pain
  • Photophobia
  • Posterior capsule opacification

Pregnancy & Lactation

  • Pregnancy Category C
  • Embryotoxic and teratogenic to rabbits
  • Use during pregnancy only if potential benefits justify potential risks to the embryo or fetus
  • Caution advised when administered to nursing mothers

Precautions & Warnings

  • Prolonged use may result in glaucoma and cataract formation
  • Monitoring of intraocular pressure if used for 10 days or longer
  • Caution required in patients with a history of herpes simplex
  • Fungal infections of the cornea prone to develop with long-term steroid application
  • Prevent dropper tip contamination

Use in Special Populations

  • Pediatric use: evaluated in 0 to 3 years age group
  • Similar safety profile observed in pediatric patients
  • No overall differences in safety or effectiveness in geriatric patients

Overdose Effects

  • Overdosage unlikely to cause acute problems
  • If accidentally ingested, dilute by drinking fluids

Therapeutic Class

  • Ophthalmic steroid preparations

Storage Conditions

  • Store at room temperature
  • Protect from light and freezing
  • Contents should not be used more than 1 month after first opening

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