Cortan 1% (Ophthalmic Suspension)

Indications

• Treatment of steroid-responsive inflammation of the palpebral and bulbar conjunctiva
• Treatment of inflammation of the cornea
• Treatment of inflammation of the anterior segment of the globe

Pharmacology

• Decreases inflammation by inhibiting migration of leukocytes
• Reverses increased capillary permeability
• Suppresses the immune system by reducing the activity and production of lymphocytes and eosinophils

Dosage & Administration

• Adult dosage: instill one drop into the conjunctival sac two to four times daily
• Initial 24-48 hours may require increased dosing frequency
• Paediatric safety and effectiveness not established

Interaction

• No significant drug interactions reported

Contraindications

• Contraindicated in viral diseases of the cornea and conjunctiva
• Contraindicated in known hypersensitivity to any of the ingredients
• Contraindicated in hypersensitivity to other corticosteroids

Side Effects

• Elevation of intraocular pressure with possible development of glaucoma
• Infrequent optic nerve damage
• Posterior subcapsular cataract formation
• Delayed wound healing
• Fungal and viral infections may develop coincidentally with long-term application

Pregnancy & Lactation

• Pregnancy category C
• Use during pregnancy only if clearly needed
• Caution should be exercised when administered to a nursing woman

Precautions & Warnings

• Shake the bottle well before use
• Prolonged use may result in damage to the optic nerve and defects in vision
• Routine monitoring of intraocular pressure if used for a longer period of time

Overdose Effects

• One-time accidental overdose generally will not cause acute problems
• Long time overdose may show general side-effects
• Sufficient water should be taken to dilute the medication in accidental overdose

Therapeutic Class

• Glucocorticoids

Storage Conditions

• Store in a cool, dry place
• Protect from light
• Keep out of the reach of children
• Protect from freezing
• Shake well before using

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