Pednisol 1% (Ophthalmic Suspension)

Indications

• Treatment of steroid-responsive inflammation of the palpebral and bulbar conjunctiva
• Treatment of steroid-responsive inflammation of the cornea
• Treatment of steroid-responsive inflammation of the anterior segment of the globe

Pharmacology

• Prednisolone decreases inflammation by inhibiting migration of polymorphonuclear leukocytes
• Prednisolone decreases inflammation by reversing increased capillary permeability
• Suppression of the immune system by reducing the activity and production of lymphocytes and eosinophils

Dosage & Administration

• Adult: One drop into the conjunctival sac two to four times daily
• Increased dosing frequency during initial 24 to 48 hours if necessary
• Care should be taken not to discontinue the therapy before completing the course

Interaction

• No significant drug interactions reported

Contraindications

• Contraindicated in viral diseases of the cornea and conjunctiva
• Contraindicated in known hypersensitivity to any of the ingredients
• Contraindicated in hypersensitivity to other corticosteroids

Side Effects

• Elevation of intraocular pressure (IOP) with possible development of glaucoma
• Infrequent optic nerve damage
• Posterior subcapsular cataract formation
• Delayed wound healing
• Fungal and viral infections of the cornea may develop with long-term applications of steroid

Pregnancy & Lactation

• Pregnancy category C
• Use during pregnancy only if clearly needed
• Caution should be exercised when administered to a nursing woman

Precautions & Warnings

• Shake the bottle well before use
• Prolonged use may result in damage to the optic nerve
• Prolonged use may result in defects in vision
• Routine monitoring of intraocular pressure is recommended for prolonged use

Overdose Effects

• One-time accidental overdose generally will not cause acute problems
• Long-term overdose may result in general side-effects
• Sufficient water should be taken to dilute the medication in case of accidental overdose

Therapeutic Class

• Glucocorticoids

Storage Conditions

• Store in a cool, dry place
• Protect from light
• Keep out of the reach of children
• Protect from freezing
• Shake well before using

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