Loval 5 mg/5 ml (Oral Suspension)
60 ml bottle: ৳ 28.19
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Jayson pharmaceuticals ltd |
| Also available as |
Title
- Loval 5 mg/5 ml Suspension
Categories
- Medicine
- Pharmacology
- Therapeutic Class: Motility Stimulants/Dopamine Antagonist
Description
- A medication primarily used to treat dyspeptic symptom complex, acute nausea and vomiting, Parkinson's disease-induced nausea and vomiting, and to speed barium transit in follow-through radiological studies
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Non-ulcer dyspepsia
- Acute nausea and vomiting
- Parkinson's disease
- Radiological studies
- Barium transit
Pharmacology
- Dopamine antagonist
- Blocks dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and stomach
- Gastroprokinetic action
- Restores normal motility and tone of the upper gastrointestinal tract
- Facilitates gastric emptying
- Enhances antral and duodenal peristalsis
- Regulates contraction of the pylorus
- Increases esophageal peristalsis
- Enhances lower esophageal sphincter pressure
DosageAndAdministration
- Should be taken 15-30 minutes before meals
- Usual recommended oral dose for adults is 10-20 mg every 6-8 hours daily, with maximum daily dose not exceeding 80 mg
- Rectal suppository administration, with doses varying for adults and children
Interactions
- Antagonizes effect of anticholinergic drugs
- Has potential interactions with CYP3A4 inhibitors
- May influence the absorption of orally administered drugs
- Does not potentiate the action of neuroleptics
- Suppresses unwanted peripheral effects of dopaminergic agonists
Contraindications
- Known hypersensitivity to domperidone
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction or perforation
- Prolactin releasing pituitary tumor (prolactinoma)
SideEffects
- Transient intestinal cramps
- Rare extrapyramidal phenomena
- Possible increase in plasma prolactin level
- Rare allergic reactions such as rash and urticaria
PregnancyAndLactation
- Considered safe in the first trimester of pregnancy if justified by therapeutic benefit
- Excreted in breast milk with concentrations 4 times lower than plasma
- Not recommended during nursing unless benefits outweigh risks
PrecautionsAndWarnings
- Increased risk of extrapyramidal reactions in young children
- Should be used with caution in patients with hepatic impairment
SpecialPopulations
- Use with caution in infants
- Use with caution in patients with liver disorders
- Use with caution in patients with severe renal insufficiency
OverdoseEffects
- Drowsiness
- Disorientation
- Extrapyramidal reactions
- Activated charcoal recommended in case of overdosage
TherapeuticClass
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
StorageConditions
- Store below 30°C
- Protect from light and moisture
- Keep out of children's reach
ChemicalStructure
- Molecular Formula: C22H24ClN5O2
- Chemical Structure: (Image of chemical structure provided)
CommonQuestions
- Usage for nausea and vomiting relief
- Precautions for driving and alcohol consumption
- Possible side effects such as dizziness, diarrhea, and stomach pain
UsabilityFeatures
- Relieves nausea
- Treats vomiting
- Improves dyspeptic symptoms
- Facilitates gastric emptying
Materials
- Active ingredient: Domperidone
TechnicalSpecifications
- Dosage strength: 5 mg/5 ml
- Maximum daily dose: 80 mg
- Availability in tablet and suspension forms
DesignElements
- Rectal suppository form available for administration
UsabilityFunctions
- Facilitates upper gastrointestinal motility
- Enhances peristalsis
- Regulates pyloric contraction
- Increases esophageal peristalsis
- Enhances lower esophageal sphincter pressure