Matropin 2% (Ophthalmic Solution)

Indications

• Use as a mydriatic and cycloplegic agent

Pharmacology

• Produces dilation and loss of accommodation by blocking the response of iris sphincter muscle and the accommodative ciliary muscle to cholinergic stimulation

Dosage & Administration

• Adult: Instill 1 or 2 drops of 2% solution
• Adult: Instill 1-2 drops of 2% or 5% solution bid-tid up to every 3-4 hr as needed
• Child: Instill 1 drop of 2% soln immediately before the procedure
• Child: 3 mth- 2 yr: instill 1 drop of 0.5% soln once daily or on alternate days. >2 yr: instill 1 drop of 1% or 2% soln bid

Interaction

• Effects may be increased by drugs with antimuscarinic effect such as some antihistamines, phenothiazines, antipsychotics, TCAs, MAOIs, or parasympathomimetics

Contraindications

• Closed-angle glaucoma or narrow angle between the iris and the cornea

Side Effects

• Hypersensitivity may occur as conjunctivitis

Pregnancy & Lactation

• Use in pregnancy: Should be used if the potential benefit justifies the potential risk to the fetus
• Use in lactation: Caution should be exercised when Matropin is administered to a nursing mother

Precautions & Warnings

• Should be used with caution in patients with prostatic enlargement and in patients suffering from paralytic ileus or pyloric stenosis

Use in Special Populations

• Should not be used in children below the age of 3 months

Overdose Effects

• Ataxia, incoherent speech, restlessness, hallucinations, disorientation, failure to recognize people and tachycardia
• Psychotic reactions and behavioural disturbances (in children)
• SC/IM/IV Physostigmine salicylate 1-2 mg to control central and peripheral effects
• Small doses of short-acting barbiturate eg. thiopentone sodium 100 mg to control excitement

Therapeutic Class

• Mydriatic and Cycloplegic agents

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