Mydrimide Plus 0.8%+5% (Ophthalmic Solution)

5 ml drop: ৳ 90.00

Medicine Details

Category Details
Generic Tropicamide phenylephrine hydrochloride
Company Reman drug laboratories ltd

Therapeutic Purpose

  • Inflammatory conditions of the uveal tract
  • Temporary lowering of intraocular pressure in glaucoma

Diagnostic Purpose

  • Retinal photography
  • Refractive errors
  • Fundus examination/photography
  • Slit lamp examination

Pre-operative Use

  • Visualization of structures behind the iris for surgical procedures like cataract extraction, vitrectomy, and retinal detachment surgery

Pharmacology

  • Tropicamide binds to and blocks the receptors in the muscles of the eye (muscarinic receptor M4)
  • Blocks the responses of the iris sphincter muscle to the iris and ciliary muscles to cholinergic stimulation
  • Produces dilation of the pupil and paralysis of the ciliary muscle
  • Phenylephrine Hydrochloride is a selective alpha-1 agonist causing mydriasis without cycloplegia
  • Reduces intraocular lesion by vasoconstrictor action

Dosage & Administration

  • Uveitis: 1-2 drops bid-qid or as required
  • Diagnostic purpose/Pre-operative purpose: Instill 1-2 drops in the eye(s) 15-20 minutes before examination
  • Additional drop may be placed in the eye(s) if examination is not conducted within 20-30 minutes to prolong the effect

Interaction

  • May interfere with the antihypertensive action of carbachol, pilocarpine or ophthalmic cholinesterase inhibitors

Contraindications

  • Hypersensitivity to any of the components
  • Narrow angles or narrow angle glaucoma
  • Low birth weight infants and some elderly adults with severe arteriosclerotic cardiovascular or cerebrovascular disease
  • During intraocular operative procedures when the corneal epithelial barrier has been disturbed

Side Effects

  • Elevated IOP (occasionally)
  • Stinging
  • Blurred vision
  • Tachycardia
  • Photophobia
  • Headache
  • Parasympathetic stimulation
  • Allergic reactions
  • Systemic effects include arrhythmias, hypertension and coronary artery spasm

Pregnancy & Lactation

  • Safety during pregnancy or lactation not established

Precautions & Warnings

  • Caution with monoamine oxidase (MAO) inhibitors
  • Consider psychotic reactions and behavioral disturbances in hypersensitive patients
  • Extreme caution in infants

Overdose Effects

  • Excessive use may produce systemic toxic symptoms

Therapeutic Class

  • Preparations for Ophthalmic diagnosis

Storage Conditions

Keep out of the reach of children. Store in a cool, dry place, away from heat and direct light. Do not use more than 4 weeks after opening

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