Timocare 0.5% (Ophthalmic Solution)

Indications

• Treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma

Pharmacology

• Non-selective β-adrenergic receptor blocker
• Reduction of aqueous humour formation
• Lowering of blood pressure

Dosage & Administration

• 0.25% or 0.5% eye drop solution
• Gel-forming eye drops
• Initial dose of 1 drop bid
• Maximum dosage
• Once daily dose for gel-forming eye drops

Interaction

• Potential interaction with epinephrine
• Interactions with beta-adrenergic blocking agents, calcium antagonists, catecholamine-depleting drugs, digitalis, quinidine, clonidine, injectable epinephrine

Contraindications

• Bronchial asthma
• Severe chronic obstructive pulmonary disease
• Sinus bradycardia
• Second or third degree atrioventricular block
• Overt cardiac failure
• Cardiogenic shock
• Hypersensitivity to any component

Side Effects

• Burning and stinging sensation of the eyes
• Bradycardia
• Hypotension
• Arrhythmia and AV or SA nodal block
• CHF
• Pulmonary edema
• Headache
• Dizziness
• Fatigue
• Asthenia
• Abdominal discomfort
• Nausea
• Constipation
• Hypoglycemia

Pregnancy & Lactation

• Use during pregnancy only if potential benefit justifies potential risk to fetus
• Detection in breast milk
• Serious adverse reactions in nursing infants

Precautions & Warnings

• Inadequate cardiac function
• Diabetes mellitus
• Myasthenia gravis
• Cerebrovascular insufficiency
• History of atopy
• Avoid abrupt withdrawal
• Major surgery
• Mask signs of hyperthyroidism and hypoglycemia
• Not to be used as monotherapy for angle-closure glaucoma
• Renal and hepatic impairment

Overdose Effects

• Inadvertent overdosage resulting in systemic effects similar to systemic beta-adrenergic blocking agents

Therapeutic Class

• Drugs for miotics and glaucoma

Storage Conditions

• Store between 15-30°C
• Avoid freezing
• Protect from light

Related Brands

• Gemolol 0.5% (Ophthalmic Solution) - general-pharmaceuticals-ltd