Motil 5 mg/5 ml (Oral Suspension)
60 ml bottle: ৳ 28.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Hallmark pharmaceuticals ltd |
| Also available as |
Title
- Motil 5 mg/5 ml Suspension
Categories
- Medicine
- Pharmaceutical
Description
- Dopamine antagonist medication for treating dyspeptic symptom complex, acute nausea and vomiting, Parkinson's disease, and speeding barium transit in radiological studies.
Ingredients
- Domperidone
ChemicalStructure
- C22H24ClN5O2
MolecularFormula
- C22H24ClN5O2
DosageForm
- Oral suspension
DosageInstructions
- Take 15-30 minutes before meals
- Maximum dose for adults: 80 mg daily
- Maximum period of treatment for acute nausea and vomiting: 12 weeks
RecommendedDoses
- Adults: 10-20 mg every 6-8 hours daily
- Adults in acute conditions: 20 mg every 6-8 hours daily
- Children: dosage based on body weight every 6-8 hours daily
- Children in acute conditions: dosage based on body weight every 6-8 hours daily
- Rectal dose for adults: 30-60 mg every 4-8 hours
- Maximum rectal dose for children: 30 mg for those weighing 10 to 25 kg
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Acute nausea and vomiting
- Parkinson's disease
- Radiological studies
Pharmacology
- Blocks dopamine receptors in Chemoreceptor Trigger Zone and stomach
- Restores normal motility and tone of upper gastrointestinal tract
- Enhances antral and duodenal peristalsis
- Regulates contraction of the pylorus
- Increases esophageal peristalsis and lower esophageal sphincter pressure
Interaction
- Antagonized by anticholinergic drugs
- Antacids and antisecretory drugs lower oral bioavailability
- Metabolized by CYP3A4
- Potential influence on absorption of concomitantly orally administered drugs
- Does not potentiate action of neuroleptics
- Suppresses unwanted peripheral effects of dopaminergic agonists
Contraindications
- Known hypersensitivity to the drug
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction or perforation
- Prolactin releasing pituitary tumor
SideEffects
- Transient intestinal cramps
- Rare extrapyramidal phenomena
- Increase in plasma prolactin level
- Hyperprolactinaemia leading to neuroendocrinological phenomena
- Rare allergic reactions like rash and urticaria
PregnancyLactation
- Use in the first trimester justified by therapeutic benefit
- No evidence of increased risk of malformations in humans
- Excreted in breast milk at 4 times lower concentration than in plasma
- Effects on ability to drive and use machines: No effect on mental alertness
PrecautionsWarnings
- Use with caution in children due to risk of extra-pyramidal reactions
- Use with caution in hepatic impairment
- Infants' immature blood-brain barrier may cause possible neurological side-effects
- Reduced dosing frequency required in severe renal insufficiency
OverdoseEffects
- Symptoms may include drowsiness, disorientation, and extrapyramidal reactions
- Activated charcoal and close patient observation recommended in case of overdosage
- Anticholinergic, antiparkinson drugs or antihistamines may help control extrapyramidal reactions
TherapeuticClass
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
StorageConditions
- Store below 30°C
- Protected from light and moisture
- Keep out of children's reach
CommonQuestions
- Used for treating nausea and vomiting
- Should be taken before meals as per prescribed dose and duration
- May cause dizziness and sleepiness
- Avoid consuming alcohol when taking it
- Dry mouth may occur as a side effect
- Do not take for longer than 7 days without consulting a doctor