Motilex 10 mg (Tablet)
Unit Price: ৳ 3.00 (10 x 10: ৳ 300.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Techno drugs ltd |
| Also available as |
Title and category
- Motilex 10 mg Tablet
- Medicine
Indication
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Acute nausea and vomiting
- Parkinson's disease
- Radiological studies
Pharmacology
- Dopamine antagonist
- Blocks dopamine receptors
- Gastroprokinetic action
- Restores normal motility and tone of upper gastrointestinal tract
- Facilitates gastric emptying
- Enhances antral and duodenal peristalsis
Dosage and administration
- Taken 15-30 minutes before meals
- Usual adult dose: 10-20 mg every 6-8 hours daily
- Children's dose based on weight
- Rectal administration for adults and children
Interaction
- Antagonistic effect with anticholinergic drugs
- Lowered oral bioavailability with antacids and antisecretory drugs
- Metabolism through CYP3A4 enzyme
- Influences absorption of orally administered drugs
Contraindications
- Hypersensitivity to domperidone
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction or perforation
- Prolactin releasing pituitary tumor
Side effects
- Transient intestinal cramps
- Rare extrapyramidal phenomena
- Increase in plasma prolactin level
- Allergic reactions such as rash and urticaria
Pregnancy and lactation
- Usage justified in first trimester if therapeutic benefit outweighs risk
- Excreted in breast milk of lactating rats
- Not recommended during nursing unless benefits outweigh risk
- No effect on mental alertness
Precautions and warnings
- Caution in children due to risk of extra-pyramidal reactions
- Caution in patients with hepatic impairment
Use in special populations
- Caution in infants due to immature blood-brain barrier
- Caution in patients with hepatic impairment
- Dosing adjustment in severe renal insufficiency
Overdose effects
- Drowsiness
- Disorientation
- Extrapyramidal reactions
- Activated charcoal recommended for overdose
Therapeutic class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage conditions
- Store below 30°C
- Protected from light and moisture
- Keep out of children's reach
Chemical structure
- Molecular Formula: C22H24ClN5O2
Commonly asked questions
- Usage to treat nausea and vomiting
- Quick tips for usage and potential side effects