Xalanol 0.005%+0.5% (Ophthalmic Solution)

2.5 ml drop: ৳ 495.00

Medicine Details

Indications

  • Reduction of intraocular pressure (IOP)
  • Treatment for open-angle glaucoma
  • Treatment for ocular hypertension
  • Insufficiently responsive to β-blockers
  • Insufficiently responsive to prostaglandins
  • Insufficiently responsive to other IOP lowering agents

Active Ingredients

  • Latanoprost
  • Timolol Maleate

Pharmacology

  • Latanoprost is an analogue of prostaglandin F<sub>2&alpha;</sub>
  • Latanoprost increases outflow of aqueous humour
  • Timolol is a non-selective adrenergic blocker
  • Timolol decreases the formation of aqueous humor by the ciliary epithelium

Dosage & Administration

  • Recommended adult dosage is one drop in the affected eye(s) once daily

Interaction

  • Observation for potential additive effects of &beta;-blockade
  • Concomitant use of two topical &beta;-adrenergic blocking agents not recommended
  • Potential mydriasis when Timolol is given with epinephrine
  • &beta;-blockers may increase hypoglycemic effect of antidiabetic agents
  • Precipitation when thimerosal and Benzalkonium chloride are mixed

Contraindications

  • Known hypersensitivity to Latanoprost
  • Known hypersensitivity to Timolol
  • Known hypersensitivity to benzalkonium chloride or any other ingredient in the product
  • Reactive airway disease including bronchial asthma
  • History of bronchial asthma or severe chronic obstructive pulmonary disease
  • Sinus bradycardia
  • Second or third degree atrioventricular block
  • Overt cardiac failure
  • Cardiogenic shock

Side Effects

  • Increased iris pigmentation
  • Darkening, thickening, and lengthening of the eye lashes
  • Irritation of the eye, including stinging, burning, and itching
  • Eye hyperaemia
  • Corneal disorders
  • Conjunctivitis blepharitis
  • Eye pain
  • Headache
  • Skin rash

Pregnancy & Lactation

  • Use during pregnancy only if potential benefit justifies potential risk to fetus
  • Latanoprost and its metabolites may pass into breast milk
  • Timolol detected in human milk following ocular administration
  • Use with caution in nursing women

Precautions & Warnings

  • Use with caution in patients with macular edema
  • Use with caution in aphakic patients
  • Use with caution in pseudophakic patients with a torn posterior lens capsule
  • Use with caution in patients with known risk factors for macular edema
  • Use with caution in patients subjected to spontaneous hypoglycemia
  • Caution for diabetic patients receiving insulin or oral hypoglycemic agents
  • Caution for patients wearing contact lenses
  • Caution for patients driving and using machines

Overdose Effects

  • Symptoms of systemic Timolol overdose are bradycardia, hypotension, bronchospasm, and cardiac arrest
  • Treatment should be symptomatic and supportive in case of overdose

Therapeutic Class

  • Drugs for miotics and glaucoma

Storage Conditions

  • Store at 2-8&deg; C
  • For opened bottles, may store below 25&deg; C

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