Myodon 10 mg (Tablet)

Title

• Myodon 10 mg Tablet

Categories

• Medicine
• Pharmaceutical

Description

• A dopamine antagonist medication used to treat nausea and vomiting

Indications

• Dyspeptic symptom complex
• Delayed gastric emptying
• Gastroesophageal reflux
• Esophagitis
• Acute nausea and vomiting
• Functional nausea and vomiting
• Nausea and vomiting induced by radiotherapy
• Nausea and vomiting induced by drug therapy
• Nausea and vomiting induced by migraine
• Parkinson's disease with dopamine-agonist induced nausea and vomiting
• Speeding barium transit in radiological studies

Pharmacology

• Dopamine antagonist
• Blocks dopamine receptors in the Chemoreceptor Trigger Zone and stomach
• Gastroprokinetic action
• Restores normal motility and tone of the upper gastrointestinal tract
• Facilitates gastric emptying
• Increases esophageal peristalsis
• Regulates contraction of the pylorus

DosageAdministration

• Should be taken 15-30 minutes before meals
• Adults: 10-20 mg every 6-8 hours daily
• Children: 2-4 ml suspension/10 kg body weight every 6-8 hours daily
• Maximum dose for adults: 80 mg daily
• Maximum period of treatment for acute nausea and vomiting: 12 weeks

Interaction

• Antagonized by anticholinergic drugs
• Lowered oral bioavailability when given simultaneously with antacids and antisecretory drugs
• Metabolized through CYP3A4
• Inhibited by CYP3A4 inhibitors such as azole antifungals and macrolide antibiotics
• May influence the absorption of orally administered drugs

Contraindications

• Known hypersensitivity to the drug
• Neonates
• Gastrointestinal hemorrhage
• Mechanical obstruction or perforation
• Prolactin releasing pituitary tumor (prolactinoma)

SideEffects

• Transient intestinal cramps
• Extrapyramidal phenomena in rare cases
• Increased plasma prolactin level
• Rare allergic reactions such as rash and urticaria

PregnancyLactation

• Can be used during the first trimester of pregnancy if justified by therapeutic benefit
• Excreted in breast milk of lactating rats
• Concentrations in breast milk 4 times lower than corresponding plasma concentrations
• Nursing not recommended unless expected benefits outweigh potential risk

PrecautionsWarnings

• Increased risk of extrapyramidal reactions in children
• Caution in patients with hepatic impairment

UseSpecialPopulations

• Caution in infants with incomplete blood-brain barrier development
• Caution in patients with hepatic impairment
• Dosing adjustment may be needed in patients with severe renal insufficiency

OverdoseEffects

• Symptoms may include drowsiness, disorientation, and extrapyramidal reactions
• Activated charcoal administration recommended
• Anticholinergic, antiparkinson drugs may be helpful in controlling extrapyramidal reactions

TherapeuticClass

• Motility Stimulants
• Dopamine antagonist
• Prokinetic drugs

StorageConditions

• Store below 30°C
• Protected from light and moisture
• Keep out of children's reach

ChemicalStructure

• Molecular Formula: C22H24ClN5O2

CommonQuestions

• Used to treat nausea and vomiting
• Helps relieve nausea, vomiting, and indigestion
• May cause dizziness and sleepiness
• Avoid consuming alcohol
• Dry mouth may occur as a side effect
• Caution in prolonged use without consulting a doctor

Related Brands

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