Noburn 10 mg (Tablet)

Unit Price: ৳ 4.00 (12 x 10: ৳ 480.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Beacon pharmaceuticals plc
Also available as
Noburn 5 mg suspension

Title

Noburn 10 mg Tablet

Categories

  • Medicine
  • Pharmaceuticals
  • Gastrointestinal Health

Description

Noburn 10 mg Tablet is a dopamine antagonist medication used to treat nausea, vomiting, and dyspeptic symptoms. It acts as a gastroprokinetic agent, enhancing gastrointestinal motility and regulating contraction of the pylorus.

Indications

  • Dyspeptic symptom complex
  • Delayed gastric emptying
  • Gastroesophageal reflux
  • Esophagitis
  • Acute nausea and vomiting
  • Parkinson's disease
  • Radiological studies

Pharmacology

  • Dopamine antagonist
  • Blocks dopamine receptors in Chemoreceptor Trigger Zone (CTZ) and stomach
  • Restores normal motility and tone of upper gastrointestinal tract
  • Facilitates gastric emptying
  • Enhances antral and duodenal peristalsis
  • Regulates contraction of the pylorus

Dosage & Administration

  • Should be taken 15-30 minutes before meals
  • Usual recommended oral dose for adults: 10-20 mg every 6-8 hours
  • Maximum dose of 80 mg daily
  • Dosage for children based on body weight
  • Rectal administration dosage for adults and children

Interaction

  • Concomitant administration of anticholinergic drugs may antagonize the antidyspeptic effect
  • Antacids and antisecretory drugs should not be given simultaneously
  • Metabolized through CYP3A4 pathway
  • Potential interaction with CYP3A4 inhibitors
  • Interactions with neuroleptics and dopaminergic agonists

Contraindications

  • Hypersensitivity to domperidone
  • Neonates
  • Gastrointestinal hemorrhage
  • Mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor

Side Effects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena
  • Increase in plasma prolactin level
  • Rare allergic reactions such as rash and urticaria

Pregnancy & Lactation

  • Use during first trimester justified by anticipated therapeutic benefit
  • Excreted in breast milk at lower levels than plasma concentrations
  • Effects on ability to drive and use machines

Precautions & Warnings

  • Increased risk of extra-pyramidal reactions in young children
  • Use with caution in patients with hepatic impairment

Use in Special Populations

  • Use in infants with caution and under medical supervision
  • Use with caution in patients with liver and kidney disorders
  • Regular review for patients on prolonged therapy

Overdose Effects

  • Symptoms may include drowsiness, disorientation, and extrapyramidal reactions
  • Recommendations for management of overdosage

Therapeutic Class

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

Storage Conditions

  • Store below 30°C
  • Protected from light and moisture
  • Keep out of children's reach

Chemical Structure

  • Molecular Formula: C22H24ClN5O2

Common Questions about Noburn 10 mg Tablet

  • Used to treat nausea and vomiting
  • Before-meal administration recommended
  • May cause dizziness and sleepiness
  • Avoid concurrent alcohol consumption
  • Potential side effects and duration of use

OtherAttributes

  • Gastroprokinetic action
  • Weak penetration across blood-brain barrier
  • Usability in radiotherapy-induced nausea and vomiting
  • Regulation of esophageal peristalsis and sphincter pressure

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