OTO-Plus 5%+1% (Ear Drop)

Indications

• Acute bacterial ear infections

Pharmacology

• Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome
• Lidocaine stabilises the neuronal membrane and inhibits Na ion movements

Dosage & Administration

• Instill 2-3 drops into the ear bid-tid for Otic/Aural Otitis externa

Interaction

• Decreased effects of iron and vitamin B12 in anaemic patients
• Phenobarbitone and rifampin reduce efficacy of chloramphenicol
• Impairs the action of oral contraceptives
• Increases the effect of oral anticoagulants
• Avoid concomitant administration with drugs that depress bone marrow function

Contraindications

• History of hypersensitivity or toxic reaction to the drug
• Perforated ear drum
• Herpes simplex and other virul conditions of the eye or ear, mycosis

Side Effects

• Ototoxicity

Pregnancy & Lactation

• Pregnancy Category C & B
• Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans
• Potential benefits may warrant use of the drug in pregnant women despite potential risks
• Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women
• Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester

Precautions & Warnings

• Avoid prolonged use
• Discontinue immediately if local hypersensitivity reactions occur

Therapeutic Class

• Aural Anti-bacterial preparations

Related Brands

• Supraphen plus 5%+1% (Ear Drop) - gaco-pharmaceuticals-ltd