Paridon 5 mg/5 ml (Oral Suspension)
100 ml bottle: ৳ 38.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Drug international ltd |
| Also available as |
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Acute nausea and vomiting
- Parkinson's disease
- Radiological studies
Pharmacology
- Dopamine antagonist
- Chemoreceptor Trigger Zone (CTZ) blocker
- Gastroprokinetic action
- Gastrointestinal motility regulation
- Gastric emptying facilitator
- Esophageal peristalsis enhancer
Dosage & Administration
- Should be taken 15-30 minutes before meals
- Maximum adult dose of 80 mg daily
- Different dosage for dyspeptic symptom and acute nausea
- Rectal suppository administration
- Reduced dose for children
Interaction
- Antagonism with anticholinergic drugs
- Oral bioavailability alteration with antacids
- Metabolic pathway through CYP3A4
- Inhibition by azole antifungals and macrolide antibiotics
- Does not potentiate neuroleptics
- Suppresses unwanted effects of dopaminergic agonists
Contraindications
- Hypersensitivity to the drug
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction
- Perforation
- Prolactin releasing pituitary tumor (prolactinoma)
Side Effects
- Transient intestinal cramps
- Rare extrapyramidal phenomena
- Increase in plasma prolactin level
- Allergic reactions like rash and urticaria
Pregnancy & Lactation
- Use only justified in first trimester
- No evidence of increased risk of malformations in humans
- Excretion in breast milk
- Not recommended during nursing
Precautions & Warnings
- Increased risk of extra-pyramidal reactions in young children
- Caution in patients with hepatic impairment
Use in Special Populations
- Caution in infants due to immature blood-brain barrier
- Caution in patients with hepatic impairment
- Limited adjustments needed in severe renal insufficiency
Overdose Effects
- Drowsiness
- Disorientation
- Extrapyramidal reactions
- Administration of activated charcoal recommended
Therapeutic Class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
Common Questions
- Used to treat nausea and vomiting
- Dosage and duration as per doctor's prescription
- May cause dizziness and sleepiness
- Avoid alcohol consumption
- Possible side effects like dry mouth and watery diarrhea