Peri 5 mg/5 ml (Oral Suspension)

100 ml bottle: ৳ 35.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Hudson pharmaceuticals ltd
Also available as
Peri 10 mg tablet

Title

  • Peri 5 mg/5 ml Suspension

Categories

  • Medicine
  • Gastrointestinal
  • Nausea and Vomiting
  • Parkinson's Disease
  • Radiological Studies

Description

  • Dopamine antagonist medication
  • Used to treat dyspeptic symptom complex, acute nausea and vomiting, Parkinson's disease, and speeding barium transit in radiological studies

Color Options

  • Clear

Function

  • Relieves nausea, vomiting, indigestion
  • Restores normal motility and tone of upper gastrointestinal tract
  • Facilitates gastric emptying
  • Enhances antral and duodenal peristalsis
  • Regulates contraction of the pylorus
  • Increases esophageal peristalsis and lower esophageal sphincter pressure
  • Prevents regurgitation of gastric content

Material

  • Chemical Structure: C22H24ClN5O2

Dosage & Administration

Should be taken 15-30 minutes before meals, maximum oral dose for adults is 80 mg daily

Indications

  • Dyspeptic symptom complex
  • Delayed gastric emptying
  • Gastroesophageal reflux and esophagitis
  • Acute nausea and vomiting
  • Parkinson's disease dopamine-agonist induced nausea and vomiting
  • Speeding barium transit in radiological studies

Pharmacology

Dopamine antagonist that blocks dopamine receptors in Chemoreceptor Trigger Zone (CTZ) and stomach

Interaction

  • Antagonizes antidyspeptic effect of anticholinergic drugs
  • Lower oral bioavailability when given simultaneously with antacids and antisecretory drugs
  • Inhibited by CYP3A4 inhibitors like azole antifungals, macrolide antibiotics, HIV protease inhibitors, nefazodone
  • Could influence absorption of concomitantly orally administered drugs

Contraindications

  • Known hypersensitivity to the drug
  • Neonates
  • Gastrointestinal hemorrhage, mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena
  • Increase in plasma prolactin level
  • Rare allergic reactions like rash and urticaria

Pregnancy & Lactation

Should be used with caution during the first trimester of pregnancy, excreted in breast milk

Precautions & Warnings

  • Caution in children
  • Caution in patients with hepatic impairment

Use in Special Populations

  • Use in infants should be with great caution and under medical supervision
  • Caution in liver disorders
  • Dosing frequency should be reduced in severe renal insufficiency

Overdose Effects

  • Drowsiness
  • Disorientation
  • Extrapyramidal reactions

Therapeutic Class

  • Motility Stimulants
  • Motility stimulants/Dopamine antagonist
  • Prokinetic drugs

Storage Conditions

Store below 30°C, protected from light & moisture, keep out of children's reach

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