Perion 5 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 33.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Globe pharmaceuticals ltd
Also available as
Perion 10 mg tablet

Title

Perion 5 mg/5 ml Suspension

Categories

  • Medicine
  • Gastrointestinal Health

Description

A dopamine antagonist medication used to treat nausea, vomiting, and dyspeptic symptom complex.

Color Options

  • Clear

Dimensions

5 mg/5 ml

Functions

  • Relieves nausea
  • Relieves vomiting
  • Improves dyspeptic symptoms
  • Enhances gastric emptying
  • Regulates contraction of the pylorus

Materials

  • Domperidone maleate

Technical Specifications

  • Molecular Formula: C22H24ClN5O2

Dosage Instructions

  • Adults:
    • 10-20 mg (1-2 tablets or 10-20 ml suspension)
    • Every 6-8 hours daily
    • Maximum dose of 80 mg daily
  • Children:
    • 2-4 ml suspension/10 kg body weight
    • 0.4-0.8 ml pediatric drops/10 kg body weight
    • Every 6-8 hours daily

Usability Features

  • Should be taken 15-30 minutes before meals
  • Avoid consuming alcohol when taking
  • Do not take for longer than 7 days without consulting a doctor

Storage Conditions

Store below 30°C, protected from light & moisture, keep out of children's reach

Pharmacology

Dopamine antagonist that blocks dopamine receptors in the CTZ and stomach, restores normal motility and tone of the upper gastrointestinal tract, enhances antral and duodenal peristalsis, regulates contraction of the pylorus

Interaction

  • Contraindications:
    • Anticholinergic drugs
    • Antacids and antisecretory drugs
    • CYP3A4 inhibitors
    • Neuroleptics
    • Dopaminergic agonists
  • Effects: May influence the absorption of orally administered drugs

Indications

  • Primary:
    • Dyspeptic symptom complex
    • Acute nausea and vomiting
    • Parkinson's disease
    • Radiological studies
  • Secondary:
    • Delayed gastric emptying
    • Gastroesophageal reflux
    • Esophagitis

Contraindications

  • Known hypersensitivity to the drug
  • Neonates
  • Gastrointestinal hemorrhage
  • Mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Extrapyramidal phenomena
  • Hyperprolactinemia
  • Allergic reactions such as rash and urticaria

Pregnancy & Lactation

  • Should only be used during the first trimester if justified by therapeutic benefit
  • Not recommended for nursing mothers unless benefits outweigh potential risk

Precautions & Warnings

  • Use with caution in children due to increased risk of extrapyramidal reactions
  • Use with caution in patients with hepatic impairment

Special Populations

  • Infants: Should be given with great caution and under close medical supervision
  • Liver Disorders: Use with caution
  • Kidney Disorders: Dosing frequency may need to be reduced in severe renal insufficiency

Overdose Effects

  • Symptoms:
    • Drowsiness
    • Disorientation
    • Extrapyramidal reactions
  • Recommended Actions:
    • Administration of activated charcoal
    • Close observation of the patient

Therapeutic Class

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

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