Cefaten 90 mg/5 ml (Powder for Suspension)

60 ml bottle: ৳ 465.00

Medicine Details

Category Details
Generic Ceftibuten dihydrate
Company Eskayef pharmaceuticals ltd
Also available as
Cefaten 400 mg capsule

Indications

  • Acute Bacterial Exacerbations of Chronic Bronchitis
  • Acute Bacterial Otitis Media
  • Pharyngitis and Tonsillitis

Pharmacology

Ceftibuten exerts its bactericidal action by binding to essential target proteins of the bacterial cell wall, leading to inhibition of cell-wall synthesis.

Dosage & Administration

  • Otitis Media:
    • Adult Dosage: 400 mg orally every 24 hours for 10 days
    • Pediatric Dosage: 9 mg/kg/day (max 400 mg) every 24 hours for 10 days
  • Tonsillitis/Pharyngitis:
    • Adult Dosage: 400 mg orally every 24 hours for 10 days
    • Pediatric Dosage: 9 mg/kg/day (max 400 mg) every 24 hours for 10 days
  • Bronchitis:
    • Adult Dosage: 400 mg orally every 24 hours for 10 days
    • Pediatric Dosage: >12 years: 400 mg orally every 24 hours for 10 days
  • Cystitis:
    • Adult Dosage: 400 mg orally every 24 hours for 7 days
    • Pediatric Dosage: >12 years: 400 mg orally every 24 hours for 7 days
  • Pneumonia:
    • Adult Dosage: 200 mg orally every 12 hours for 7-14 days
    • Pediatric Dosage: >12 years: 200 mg orally every 12 hours for 7-14 days
  • Sinusitis:
    • Adult Dosage: 400 mg orally every 24 hours for 10-14 days
    • Pediatric Dosage: >12 years: 400 mg orally every 24 hours for 10-14 days
  • Urinary tract Infection:
    • Adult Dosage: 400 mg orally every 24 hours for 10 days
    • Pediatric Dosage: 9 mg/kg/day (max 400 mg) every 24 hours for 10 days

Interaction

Theophylline & Antacid do not alter the pharmacokinetic profile of Cefaten. Ranitidine increases the Cmax & AUC of Cefaten.

Contraindications

Ceftibuten is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Side Effects

  • Nausea
  • Headache
  • Diarrhea
  • Dyspepsia
  • Dizziness
  • Abdominal Pain
  • Vomiting

Pregnancy & Lactation

Pregnancy Category B. Caution should be exercised when Ceftibuten is administered to nursing women.

Precautions & Warnings

Prolonged treatment may result in the possible emergence and overgrowth of resistant organisms. Careful observation of the patient is essential. Dose of Cefaten may require adjustment in patients with varying degrees of renal insufficiency. Cefaten should be prescribed with caution to individuals with a history of gastrointestinal disease, particularly colitis.

Use in Special Populations

  • Renal Impairment:
    • CrCl 5-29 ml/min: 2.25 mg/kg or 100 mg orally once a day
    • CrCl 30-49 ml/min: 4.5 mg/kg or 200 mg orally once a day
  • Hepatic Impairment: Dose adjustment is not necessary.

Therapeutic Class

Third generation Cephalosporins

Reconstitution

  • The small bottle contains purified water and large bottle contains granules
  • Prepared suspension to be consumed within 14 days of preparation if kept in a refrigerator

Storage Conditions

Store below 25°C, protected from light and moisture. After reconstitution, the suspension may be used for 14 days while stored at 2°-8°C. Keep out of reach of children.

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