Prokinet 5 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 40.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Nipro jmi pharma ltd
Also available as
Prokinet 10 mg tablet

Indications

  • Dyspeptic symptom complex including epigastric fullness, abdominal pain, nausea, and vomiting
  • Acute nausea and vomiting
  • Parkinson's disease-related nausea and vomiting
  • Speeding barium transit in radiological studies

Pharmacology

  • Dopamine antagonist action
  • Blockage of dopamine receptors in CTZ and stomach
  • Gastroprokinetic action
  • Enhancement of gastric emptying and intestinal peristalsis

Dosage & Administration

  • Adults:
    • 10-20 mg, every 6-8 hours daily
    • Maximum dose of 80 mg daily
  • Children:
    • 2-4 ml suspension/10 kg body weight
    • 0.4-0.8 ml paediatric drops/10 kg body weight

Interactions

  • Antagonism with anticholinergic drugs
  • Lowered oral bioavailability with antacids and antisecretory drugs
  • Metabolic pathway through CYP3A4
  • Potential interaction with azole antifungals and macrolide antibiotics

Contraindications

  • Known hypersensitivity to domperidone
  • Neonates
  • Gastrointestinal hemorrhage, mechanical obstruction, or perforation
  • Prolactin releasing pituitary tumor

Side Effects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena
  • Increase in plasma prolactin level
  • Rare allergic reactions like rash
  • Potential neuroendocrinological effects

Pregnancy & Lactation

  • Use in first trimester justified by therapeutic benefit
  • No evidence of increased risk of malformations in humans
  • Excretion in breast milk at lower concentrations

Precautions & Warnings

  • Increased risk of extrapyramidal reactions in young children
  • Use with caution in hepatic impairment

Use in Special Populations

  • Caution in infants due to immature blood-brain barrier
  • Caution in hepatic impairment
  • Adjustment of dosing in severe renal insufficiency

Overdose Effects

  • Drowsiness
  • Disorientation
  • Extrapyramidal reactions
  • Activated charcoal administration

Therapeutic Class

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

Storage Conditions

  • Store below 30°C
  • Protected from light and moisture

Chemical Structure

  • Molecular Formula: C22H24ClN5O2
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg

Common Questions

  • Usage: Treatment of nausea and vomiting
  • Quick Tips:
    • Relieves nausea, vomiting, and indigestion
    • Caution in activities requiring mental focus
    • Avoid alcohol consumption
    • Management of dry mouth
    • Consult doctor if symptoms persist beyond 7 days

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