Virodacla 60 mg (Tablet)

Unit Price: ৳ 400.00 (3 x 4: ৳ 4,800.00)
Strip Price: ৳ 1,600.00

Medicine Details

Category Details
Generic Daclatasvir
Company Incepta pharmaceuticals ltd

Indications

  • Treatment of chronic hepatitis C virus (HCV) infection in adults

Pharmacology

  • Direct acting antiviral agent (DAA) against the Hepatitis C Virus (HCV)
  • Inhibitor of NS5A, a nonstructural protein encoded by HCV
  • Binds to the N-terminus of NS5A and inhibits viral RNA replication and virion assembly

Dosage & Administration

  • Recommended dosage of 60mg once daily, to be taken orally with or without meals
  • Administered in combination with other medicinal products
  • Dose modification and interruption guidelines

Interaction

  • Substrate of CYP3A
  • Inhibitor of P-glycoprotein transporter (P-gp), organic anion transporting polypeptide (OATP) 1B1 and 1B3, and breast cancer resistance protein (BCRP)

Contraindications

  • Contraindicated in combination with drugs that strongly induce CYP3A
  • Includes anticonvulsants, antimycobacterial agents, and herbal products like st.Jhon’s wort (Hypericum perforatum)

Side Effects

  • Serious symptomatic bradycardia when coadministered with Sofosbuvir and Amiodarone
  • Symptoms may include fainting, dizziness, weakness, chest pain, confusion

Pregnancy & Lactation

  • No data available for pregnant women or breastfeeding
  • Effects on the breastfed infant or milk production is unknown

Precautions & Warnings

  • Risk of adverse reactions or loss of virologic response due to drug interactions
  • Potential for known or potentially significant drug interactions
  • Serious symptomatic bradycardia when coadministered with Sofosbuvir and Amiodarone

Use in Special Populations

  • No dose adjustment required for elderly patients and those with renal impairment
  • No dose adjustment for patients with mild to severe hepatic impairment
  • Safety and efficacy in children and adolescents below 18 years not established

Overdose Effects

  • No known antidote for overdose
  • Treatment should consist of general supportive measures
  • Dialysis unlikely to significantly reduce plasma concentrations

Therapeutic Class

  • Hepatic viral infections (Hepatitis C)

Storage Conditions

  • Store at room temperature below 30°C
  • Protect from light
  • Keep out of the reach of children

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