Dapaglip 5 mg (Tablet)
Unit Price: ৳ 16.00 (3 x 10: ৳ 480.00)
Strip Price: ৳ 160.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Dapagliflozin propanediol |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
Pharmacology
- Inhibitor of Sodium-glucose co-transporter 2 (SGLT2)
- Reduces reabsorption of filtered glucose and lowers the renal threshold for glucose
Dosage & Administration
- Recommended starting dose of 5 mg once daily for adults
- Assessment of renal function recommended prior to initiation
- Safety and efficacy in children and adolescents not established
Interaction
- May add to the diuretic effect of thiazide and loop diuretics
- May have interaction with insulin and insulin secretagogues, antihypertensives, pioglitazone, GLP-1 agonists, etc.
Contraindications
- Known hypersensitivity to Dapagliflozin or any excipients
- Severe renal impairment, end-stage renal diseases, or patients on dialysis
Side Effects
- Hypotension
- Ketoacidosis
- Acute kidney injury
- Impairment in renal function
- Hypoglycemia with concomitant use with insulin and insulin secretagogues
- Genital mycotic infections
- Increases in low-density lipoprotein cholesterol (LDL-C)
- Nasopharyngitis
- Urinary tract infection
- Bladder cancer
Pregnancy & Lactation
- Pregnancy category C
- Use during pregnancy only if potential benefit justifies potential risk to the fetus
- Not to be used during lactation
Precautions & Warnings
- Assess volume status and correct hypovolemia before initiating
- Monitor renal function during therapy
- Consider lower dose of insulin or insulin secretagogue to reduce risk of hypoglycemia
- Use with caution in patients with a prior history of bladder cancer
Therapeutic Class
- Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors
Storage Conditions
- Store in a cool and dry place protected from light, below 30°C