Prolong 60 mg (Tablet)
Unit Price: ৳ 50.00 (1 x 4: ৳ 200.00)
Strip Price: ৳ 200.00
Medicine Details
Category | Details |
---|---|
Generic | Dapoxetine hydrochloride |
Company | Ziska pharmaceuticals ltd |
Also available as |
Indications
- Treatment of premature ejaculation in men 18 to 64 years of age
- Persistent or recurrent ejaculation with minimal sexual stimulation
- Marked personal distress or interpersonal difficulty as a consequence of PE
- Poor control over ejaculation
Pharmacology
- Inhibition of neuronal reuptake of serotonin
- Potentiation of neurotransmitter's action at pre-and post synaptic receptors
- Sympathetic nervous system mediation of human ejaculation
- Rapid absorption with maximum plasma concentrations occurring approximately 1-2 hours after tablet intake
- Absolute bioavailability of 42%
- Extensive metabolism to multiple metabolites primarily through biotransformational pathways
- Rapid distribution with a mean steady state volume of distribution of 162 L
- Rapid elimination with a terminal half-life of approximately 19 hours
Dosage & Administration
- Recommended starting dose of 30 mg for adult men
- Maximum recommended dosing frequency of once every 24 hours
- Caution advised in patients with mild or moderate renal impairment
- Contraindicated in patients with moderate and severe hepatic impairment
Interaction
- Caution advised when using Prolong in combination with CNS active medicinal products
- Prescribed with caution in patients who use PDE5 inhibitors
- Prescribed with caution in patients who use alpha adrenergic receptor antagonists
- Caution advised when used in patients taking Warfarin chronically
- Concomitant use of alcohol and Prolong could increase the chance or severity of adverse reactions
Contraindications
- Known hypersensitivity to Dapoxetine Hydrochloride
- Significant pathological cardiac conditions
- Concomitant treatment with monoamine oxidase inhibitors (MAOIs) or thioridazine
- Concomitant treatment with serotonin reuptake inhibitors or other medicinal/herbal products with serotonergic effects
Side Effects
- Nausea
- Dizziness
- Dry mouth
- Headache
- Diarrhea
- Insomnia
- Low rates of sexual dysfunction
- Mild adverse effects on loss of libido and ED
Pregnancy & Lactation
- Not indicated for use by women
- Excretion through human breast milk unknown
Precautions & Warnings
- Patients advised not to use Prolong in combination with recreational drugs
- Combining alcohol with Prolong may increase alcohol-related neurocognitive effects
- Patients need to be made aware that they could experience syncope at any time
- An orthostatic test should be performed before initiating therapy
- Caution advised in patients taking Prolong with medicinal products known to affect platelet function
- Prescribed with caution in patients who use alpha adrenergic receptor antagonists
Overdose Effects
- No case of overdose reported
- Symptoms of overdose with SSRIs include serotonin-mediated adverse reactions
- No evidence of withdrawal syndrome in clinical trial
Therapeutic Class
- Drugs for Erectile Dysfunction
Storage Conditions
- Store below 30°C
- Protect from light and moisture
- Keep out of reach of children