Prolong 60 mg (Tablet)

Unit Price: ৳ 50.00 (1 x 4: ৳ 200.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Dapoxetine hydrochloride
Company Ziska pharmaceuticals ltd
Also available as
Prolong 30 mg tablet

Indications

  • Treatment of premature ejaculation in men 18 to 64 years of age
  • Persistent or recurrent ejaculation with minimal sexual stimulation
  • Marked personal distress or interpersonal difficulty as a consequence of PE
  • Poor control over ejaculation

Pharmacology

  • Inhibition of neuronal reuptake of serotonin
  • Potentiation of neurotransmitter's action at pre-and post synaptic receptors
  • Sympathetic nervous system mediation of human ejaculation
  • Rapid absorption with maximum plasma concentrations occurring approximately 1-2 hours after tablet intake
  • Absolute bioavailability of 42%
  • Extensive metabolism to multiple metabolites primarily through biotransformational pathways
  • Rapid distribution with a mean steady state volume of distribution of 162 L
  • Rapid elimination with a terminal half-life of approximately 19 hours

Dosage & Administration

  • Recommended starting dose of 30 mg for adult men
  • Maximum recommended dosing frequency of once every 24 hours
  • Caution advised in patients with mild or moderate renal impairment
  • Contraindicated in patients with moderate and severe hepatic impairment

Interaction

  • Caution advised when using Prolong in combination with CNS active medicinal products
  • Prescribed with caution in patients who use PDE5 inhibitors
  • Prescribed with caution in patients who use alpha adrenergic receptor antagonists
  • Caution advised when used in patients taking Warfarin chronically
  • Concomitant use of alcohol and Prolong could increase the chance or severity of adverse reactions

Contraindications

  • Known hypersensitivity to Dapoxetine Hydrochloride
  • Significant pathological cardiac conditions
  • Concomitant treatment with monoamine oxidase inhibitors (MAOIs) or thioridazine
  • Concomitant treatment with serotonin reuptake inhibitors or other medicinal/herbal products with serotonergic effects

Side Effects

  • Nausea
  • Dizziness
  • Dry mouth
  • Headache
  • Diarrhea
  • Insomnia
  • Low rates of sexual dysfunction
  • Mild adverse effects on loss of libido and ED

Pregnancy & Lactation

  • Not indicated for use by women
  • Excretion through human breast milk unknown

Precautions & Warnings

  • Patients advised not to use Prolong in combination with recreational drugs
  • Combining alcohol with Prolong may increase alcohol-related neurocognitive effects
  • Patients need to be made aware that they could experience syncope at any time
  • An orthostatic test should be performed before initiating therapy
  • Caution advised in patients taking Prolong with medicinal products known to affect platelet function
  • Prescribed with caution in patients who use alpha adrenergic receptor antagonists

Overdose Effects

  • No case of overdose reported
  • Symptoms of overdose with SSRIs include serotonin-mediated adverse reactions
  • No evidence of withdrawal syndrome in clinical trial

Therapeutic Class

  • Drugs for Erectile Dysfunction

Storage Conditions

  • Store below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Related Brands