Deflacort 6 mg (Tablet)
Unit Price: ৳ 9.50 (6 x 10: ৳ 570.00)
Strip Price: ৳ 95.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Deflazacort |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Anaphylaxis
- Asthma
- Rheumatoid arthritis
- Juvenile chronic arthritis
- Systemic lupus erythematosus
- Dermatomyositis
- Mixed connective tissue disease
- Polyartritis nodosa
- Sarcoidosis
- Pemphigus
- Bullous pemphigoid
- Pyoderma gangrenosum
- Minimal change nephrotic syndrome
- Acute interstitial nephritis
- Rheumatic carditis
- Ulcerative colitis
- Crohn's disease
- Uveitis
- Optic neuritis
- Autoimmune haemolytic anaemia
- Idiopathic thrombocytopenic purpura
- Acute lymphatic leukaemia
- Malignant lymphoma
- Multiple myeloma
- Immune suppression in transplantation
Pharmacology
- Anti-inflammatory action
- Inhibition of Phospholipase A2 enzyme
- Prostaglandin synthesis inhibition
- Immunosuppressive action
- Inhibition of release of certain chemicals in immune system
Dosage & Administration
- Adults up to 120 mg/day for acute disorders
- Maintenance doses in the range of 3-18 mg/day for most conditions
- Maintenance dose for rheumatoid arthritis
- High doses for bronchial asthma treatment
- Children's dosage guidance
- Deflazacort withdrawal protocol
Interaction
- Metabolism in the liver
- Increased maintenance dose with liver enzyme inducers
- Possible reduction in maintenance dose with liver enzyme inhibitors
Contraindications
- Hypersensitivity to any of the ingredients
- Patients receiving live virus immunization
Side Effects
- GI disturbances
- Musculoskeletal effects
- Endocrine effects
- Neuropsychiatric effects
- Ophthalmic effects
- Fluid and electrolyte disturbances
- Susceptibility to infection
- Impaired healing
- Hypersensitivity reactions
- Skin atrophy
- Striae
- Telangiectasia
- Acne
- Myocardial rupture risk following recent MI
- Thromboembolism risk
Pregnancy & Lactation
- Placental crossing
- Risk of intrauterine growth retardation with prolonged or repeated administration during pregnancy
- Excretion in breast milk
- Unlikely systemic effects in infant with doses up to 50 mg daily
- Degree of adrenal suppression in infants of mothers taking higher doses
Precautions & Warnings
- Caution in cardiac disease or congestive heart failure
- Hypertension monitoring
- Thromboembolic disorder monitoring
- Salt and water retention risk
- Increased excretion of potassium risk
- Caution in gastritis or oesophagitis
- Ulcerative colitis caution
- Diabetes mellitus caution
- Osteoporosis caution
- Renal insufficiency caution
- Emotional instability caution
- Psychotic tendency caution
- Epilepsy caution
- Corticosteroid-induced myopathy history caution
- Liver failure caution
- Hypothyroidism and cirrhosis caution
- Ocular herpes simplex caution
Use in Special Populations
- Dose adjustment in hepatic impairment
- Renal impairment precautions
- No special precautions in elderly patients
Therapeutic Class
- Glucocorticoids
Storage Conditions
- Cool and dry place below 25°C
- Protected from light and moisture
- Keep out of the reach of children