Fixolin 400 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Doxophylline |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Bronchial asthma
- Bronchospasm
- Chronic obstructive pulmonary disease (COPD)
- Pulmonary disease with spastic bronchial component
Pharmacology
- Novel bronchodilator
- Selective inhibition of phosphodiesterase 4
- Relaxes bronchial smooth muscle
- Decreased affinities toward adenosine A1 and A2 receptors
- Inhibition of platelet activating factor (PAF)
- Inhibition of leukotriene production
Dosage & Administration
- 200 mg tablet dosage for elderly
- 400 mg tablet dosage for adults
- Dosage for children based on age and body weight
- Special release tablet for 400 mg daily dose
- Physician's prescribed dosage
Interaction
- Avoid administering with other xanthine preparations
- Limit consumption of caffeine-containing beverages and food
- Exercise caution with sympathomimetic drugs
- Concurrent administration with specific medications may affect hepatic clearance
- Specific drugs that may increase or decrease drug clearance
- Possible need to adjust dosage in certain cases
Contraindications
- Known hypersensitivity to doxophylline or xanthine derivatives
- Acute myocardial infarction
- Hypotension
- Lactation
Side Effects
- Nausea
- Vomiting
- Epigastric pain
- Headache
- Irritability
- Insomnia
- Tachycardia
- Extrasystoles
- Tachypnea
- Hyperglycemia
- Albuminuria
- Severe cardiac arrhythmias
- Tonic-clonic seizure
Pregnancy & Lactation
- Animal test findings
- Insufficient clinical evidence during pregnancy
- Evaluation of risk-benefit ratio for pregnancy use
- Contraindicated during lactation
- No effect on ability to drive and use machines
Precautions & Warnings
- Factors reducing hepatic clearance of xanthine derivatives
- Monitoring blood levels in certain cases
- Caution in patients with various medical conditions
- Slower clearance in congestive heart failure patients
- No risk of addiction or dependence
Overdose Effects
- Severe cardiac arrhythmias
- Tonic-clonic seizure
- Treatment of cardiovascular collapse
- Resuming treatment at lower doses after toxicity subsides
Therapeutic Class
- Bronchodilator
- Methyl xanthine derivatives
Storage Conditions
- Keep in dry place away from light and heat
- Keep out of the reach of children
- Use only on prescription of specialist physician