Vave 5 mg/5 ml (Oral Suspension)
60 ml bottle: ৳ 35.11
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Aci limited |
| Also available as |
Product Title
- Vave 5 mg/5 ml Suspension
Categories
- Medicine
- Gastrointestinal
- Nausea and Vomiting
Description
- Dyspeptic symptom relief management
- Acute nausea and vomiting treatment
- Treatment for Parkinson's disease-induced nausea and vomiting
- Speeding barium transit in follow-through radiological studies
Formulation
- Suspension
Dosage Form
- 5 mg/5 ml
Active Ingredient
- Domperidone
Pharmacological Action
- Dopamine antagonist
- Blocks dopamine receptors in Chemoreceptor Trigger Zone (CTZ) and stomach
- Restores normal motility and tone of upper gastrointestinal tract
- Facilitates gastric emptying
- Enhances antral and duodenal peristalsis
- Regulates contraction of the pylorus
- Increases esophageal peristalsis
- Regulates lower esophageal sphincter pressure
- Prevents regurgitation of gastric content
Administration
- Should be taken 15-30 minutes before meals and, if necessary, before retiring
- Usual recommended oral dose for Adults: 10-20 mg every 6-8 hours daily
- Usual recommended oral dose for Children: 2-4 ml/10 kg body weight every 6-8 hours daily
- Rectal administration for Adults: 30-60 mg every 4-8 hours
- Rectal administration for Children: Up to 30 mg
Interactions
- Anticholinergic drugs may antagonize the antidyspeptic effect
- Simultaneous administration with antacids and antisecretory drugs lowers oral bioavailability
- Main metabolic pathway is through CYP3A4
- In vitro data suggests concomitant use of CYP3A4 inhibitors may increase plasma levels
- Influence on the absorption of orally administered drugs, particularly sustain release or enteric coated formulations
- Does not potentiate neuroleptics
- Suppresses unwanted peripheral effects of dopaminergic agonists
Contraindications
- Known hypersensitivity to the drug
- Neonates
- Gastrointestinal hemorrhage, mechanical obstruction, or perforation
- Prolactin releasing pituitary tumor (prolactinoma)
Side Effects
- Transient intestinal cramps
- Rare extrapyramidal phenomena
- Increase in plasma prolactin level
- Rare allergic reactions such as rash and urticaria
Pregnancy & Lactation
- Should only be used during the first trimester if justified by therapeutic benefit
- No evidence of increase in risk of malformations
- Excreted in breast milk
- Not recommended for nursing mothers unless benefits outweigh potential risk
Precautions & Warnings
- Use with caution in children due to increased risk of extra-pyramidal reactions
- Use with caution in patients with hepatic impairment
Use in Special Populations
- Use in infants with great caution and under close medical supervision
- Use with caution in patients with liver and kidney disorders
Overdose Effects
- Symptoms may include drowsiness, disorientation, and extrapyramidal reactions
- Administration of activated charcoal, and close observation recommended
- Anticholinergic, antiparkinson drugs or antihistamines may be helpful in controlling extrapyramidal reactions
Therapeutic Class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
- Chemical Structure Image: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg
Commonly Asked Questions
- Used to treat nausea and vomiting
- Helps relieve nausea, vomiting, and indigestion
- May cause dizziness and sleepiness, caution while driving or operating machinery
- Avoid consuming alcohol while taking the suspension
- Dry mouth may occur as a side effect, maintain good oral hygiene
- Do not take the suspension for longer than 7 days without consulting a doctor