Levofed 2 mg/2 ml (IV Infusion)
2 ml ampoule: ৳ 250.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Norepinephrine bitartrate |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- Control of blood pressure in acute hypotensive states
- Adjunct in treatment of cardiac arrest and profound hypotension
Pharmacology
- Direct-acting sympathomimetic
- Stimulates β1- and α-adrenergic receptors
- Causes vasoconstriction to raise blood pressure with reflex slowing of heart rate
Dosage & Administration
- Infusion should be given into a large vein
- Diluted in 5 percent dextrose injection or 5 percent dextrose and sodium chloride injections
- Average dosage is 4 mcg/ml in 5 percent dextrose solution
- High dosage may be necessary based on patient response
Interaction
- Increased cardiac irritability with cyclopropane and halothane anesthesia
- Caution with monoamine oxidase inhibitors or tricyclic antidepressants
Contraindications
- Hypotension from blood volume deficits
- Mesenteric or peripheral vascular thrombosis
- Use with cyclopropane and halothane anesthesia
- Avoid in patients with profound hypoxia or hypercarbia
Side Effects
- Ischemic injury
- Bradycardia
- Arrhythmias
- Anxiety
- Headache
- Respiratory difficulty
- Extravasation necrosis at injection site
- Plasma volume depletion
- Gangrene of extremities
Pregnancy & Lactation
- Pregnancy Category C
- Caution in nursing women
Precautions & Warnings
- Avoid hypertension
- Monitor blood pressure during administration
- Prevent extravasation necrosis
- Use large veins for infusion
- Antidote for extravasation ischemia
Use in Special Populations
- Safety and effectiveness in pediatric patients not established
- Caution in geriatric patients
- No studies on carcinogenesis, mutagenesis, or impairment of fertility
Overdose Effects
- Headache
- Severe hypertension
- Reflex bradycardia
- Increased peripheral resistance
- Decreased cardiac output
Therapeutic Class
- Alpha and Beta-adrenergic agonist
Reconstitution
- Dilute with 5% glucose injection with or without sodium chloride
Storage Conditions
- Store at a temperature not exceeding 30°C
- Protect from light
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