Racetril 100 mg (Capsule)

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Racecadotril
Company Incepta pharmaceuticals ltd
Also available as
Racetril 10 mg powder Racetril 30 mg powder

Indications

  • Symptomatic treatment of acute diarrhea

Description

  • Pure intestinal antisecretory active substance
  • Decreases intestinal hypersecretion of water and electrolytes induced by cholera toxin or inflammation
  • Rapidly absorbed and hydrolyzed to thiorphan
  • Inhibitor of enkephalinase
  • Protects enkephalins from enzymatic degradation
  • Exerts rapid antidiarrheal action

Pharmacology

  • Increases availability of endogenous opioids (enkephalins)
  • Inhibits membrane-bound enkephalinase
  • Mediates effect through δ receptor activation
  • Selective increase in Cl absorption by inhibiting adenylate cyclase
  • Onset: 30 min (plasma enkephalinase inhibition)

Dosage & Administration

  • Adult dosage: one capsule initially, then one capsule three times daily before main meals
  • Children dosage: determined according to body weight
  • Infants less than 9 kg: one 10 mg sachet 3 times daily
  • Infants 9 kg to 13 kg: two 10 mg sachets 3 times daily
  • Children 13 kg to 27 kg: one 30mg sachet 3 times daily
  • Children more than 27 kg: two 30mg sachets 3 times daily

Interaction

  • No drug interactions found
  • Joint treatment with Racetril and Loperamide or Nifuroxazide does not modify Racetril kinetics

Contraindications

  • Hypersensitivity to Racecadotril or any excipients

Side Effects

  • Headache
  • Erythema multiforme
  • Urticaria
  • Angioedema

Pregnancy & Lactation

  • Not recommended for pregnant or breastfeeding women due to lack of clinical data

Precautions & Warnings

  • Does not modify usual rehydration regimens
  • Caution in patients with renal or liver impairment
  • Not tested in antibiotic-associated diarrhea
  • Should not be administered in case of bloody stools and fever

Overdose Effects

  • No reported cases of overdose
  • Single doses above 2 g in adults have not caused harmful effects

Therapeutic Class

  • Anti-diarrheal

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