Radola 100 mg (Capsule)

Indications

• Symptomatic treatment of acute diarrhea

Description

• Pure intestinal antisecretory active substance
• Rapid absorption
• Hydrolyzed to thiorphan
• Inhibitor of enkephalinase
• Protects enkephalins from enzymatic degradation
• Prolongs enkephalin action in small intestine
• Reduces hypersecretion
• Rapid antidiarrhoeal action
• Does not modify duration of intestinal transit

Pharmacology

• Increases availability of endogenous opioids
• Inhibits membrane-bound enkephalinase
• Mediates effects through delta opioid receptor
• Selective increase in Cl absorption
• Inhibits adenylate cyclase
• Onset: 30 min (plasma enkephalinase inhibition)

Dosage & Administration

• Adult dosage: one capsule initially, then one capsule three times daily
• Children dosage determined by body weight
• Racecadotril granules for children from 3 months of age
• Infants less than 9 kg: one 10 mg sachet 3 times daily
• Infants from 9 kg to 13 kg: two 10 mg sachets 3 times daily
• Children from 13 kg to 27 kg: one 30mg sachet 3 times daily
• Children of more than 27 kg: two 30mg sachets 3 times daily

Interaction

• No drug interactions found
• Joint treatment with Loperamide or Nifuroxazide does not modify the kinetics

Contraindications

• Hypersensitivity to Racecadotril or excipients

Side Effects

• Headache
• Erythema multiforme
• Urticaria
• Angioedema

Pregnancy & Lactation

• Not recommended for pregnant or breastfeeding women due to lack of clinical data

Precautions & Warnings

• Does not modify usual rehydration regimens
• Caution with bloody stools and fever
• Not tested in antibiotic-associated diarrhea
• Caution in patients with renal or liver impairment

Overdose Effects

• No reported overdose cases
• Single doses above 2 g in adults have not caused harmful effects

Therapeutic Class

• Anti-diarrhoeal

Related Brands

• Racedot 100 mg (Capsule) - square-pharmaceuticals-plc
• Rehydril 100 mg (Capsule) - ibn-sina-pharmaceuticals-ltd