Sovalvir 400 mg (Tablet)
Unit Price: ৳ 861.71 (1 x 7: ৳ 6,032.00)
Strip Price: ৳ 6,032.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sofosbuvir |
| Company | Healthcare pharmaceuticals ltd |
Indications
- Treatment of chronic hepatitis C
- Efficacy for HCV genotypes 1, 2, 3, 4
- Treatment of hepatocellular carcinoma
- Treatment of HCV/HIV-1 co-infection
- Monotherapy not recommended
- Treatment regimen dependent on viral genotype and patient population
- Treatment response variation based on baseline factors
Pharmacology
- Nucleotide analog inhibitor
- Inhibits HCV NS5B RNA-dependent RNA polymerase
- Incorporates into HCV RNA and acts as a chain terminator
- Prevents HCV viral replication by binding to Mg2+ ions
Dosage & Administration
- One 400 mg tablet daily with or without food
- Combination therapy with Peginterferon alfa and Ribavirin
- Recommended therapy duration for different genotypes
Interaction
- Reduced therapeutic effect with P-gp inducers
- Potential bradycardia with amiodarone co-administration
Contraindications
- Contraindicated in pregnant women
- Contraindicated in men with pregnant partners
Side Effects
- Common adverse events: fatigue, headache, nausea, insomnia, anemia
- Other adverse events observed
Pregnancy & Lactation
- Pregnancy Category B
- No well-controlled studies in pregnant women
- Unknown presence in human breast milk
Precautions & Warnings
- Risk of bradycardia with amiodarone co-administration
- Cardiac monitoring recommended in specific cases
Use in Special Populations
- Safety and effectiveness in children not established
- No dose adjustment required for geriatric patients
Overdose Effects
- Single dose of Sovalvir 1200 mg
- No specific antidote available
- General supportive measures for overdose treatment
Therapeutic Class
- Hepatic viral infections
Storage Conditions
- Keep out of reach of children
- Store in cool, dry place
- Protect from light